期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

三氧化二砷联合维甲酸治疗骨髓增生异常综合征 被引量：9

CLINICAL OBSERVATION ON ARSENIC TRIOXIDE ASSOCIATED WITH ATRA IN THE TREATMENT OF MYELODYSPLASTIC SYNDROME
原文传递
导出
摘要 目的:探讨三氧化二砷联合维甲酸(ATRA)治疗MDS的疗效。方法:31例MDS患者均采用三氧化二砷联合维甲酸等治疗。结果:RA+RAS组有效率87.1 %,RAEB+RAEB蛳T组有效率42.9 %。结论:三氧化二砷是一种治疗MDS的有效药物,尤其是在RA的治疗中有显著效果。 Objective: To observe the efficacy of arsenic trioxide cssocidted with ATRA in the treatment of MDS. Methods: 31 cases MDS patients were enrolled in this trial. The arsenic trioxide associated with ATRA was admitted to these MDS patients. Results: 20 of 21 cases of the MDS RA patients showed the improvement and the rate of the improvement is 87.1 %. Conclusion: Arsenic trioxide is a new and effective drug in the treatment of MDS, especially in the RA subgroup.
作者 刘新建 陈玲 王珊 段璐芬 杨延良 苏丽娟 王喜莲 王鸿勋 席雨人
机构地区 平顶山市新华区人民医院血液科 平顶山市第一人民医院血液科 郑州大学第一附属医院血液科
出处 《白血病．淋巴瘤》 CAS 2004年第2期96-97,共2页 Journal of Leukemia & Lymphoma
关键词 骨髓增生异常综合征 亚砷酸 维甲酸 MDS Arsenic trioxide ATRA
分类号 R551.3 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献3

二级参考文献12

  • 1赵卫红 寿好长 阎福岭.细胞凋亡[M].河南：河南医科大学出版社,1998.50.
  • 2魏亚明 欧英贤 路继红 等.The apoptosis of HL-60,K562 and NB4 cells induced by arsenic trioxide [J].Medical Journal of National Defending Forces in Northwest China(西北国防医学杂志),.
  • 3Raza A,Gezer S,Mundle S,et al. Apoptosis in bone marrow biopsy samles involving stromal and hematopoietic cells in 50patients with myelodysplastic syndromes[J]. Blood, 1995,86 :268-272.
  • 4Raza A,Mundle S,Iftikhar A,et al. Simultaneous assessment of cell kinetics and programmed cell death in bone morrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis[J]. Am J Hematol,1995,48:143-148.
  • 5Penney N S,Boaert M,Serfling V,et al. PCNA expression in cutaneous keratinous neoplasms and verruca vulgous [J]. Am J Pathol, 1992,141:139- 141.
  • 6Yang J,Liu X,Bhalla K,et al. Prevention of apoptosis by bcl2: release of cytochrome c from mitochondria blocked[J]. Science, 1997,275:1129- 1130.
  • 7Porwit Mac Donald A,Ivory K,Wilkinson S,et al. Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia [J]. Leukemia, 1995 (9): 1191 -1194.
  • 8Bradbury D,Zhu Y M,unter A,et al. Acute myeloblastic leukemia cells with autonomous growth express high levels of bcl-2 protein which is regulated by autocrine growth factors[J]. Blood, 1993,82 (Suppl 1): 124a.
  • 9Delforge M,van Duppen V,Demuynck H,et al. Clonality study of hematopoietic marrow progenitors and mature blood cells in patients with myelodysplastic syndromes [J]. Blood, 1995,86:335.
  • 10Prindull G. Apoptosis in the embryo and tumorigenesis[J].Eur J Cancer,1995,31A:116-119.

共引文献32

同被引文献150

引证文献9

二级引证文献28

白血病．淋巴瘤
2004年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部