摘要
目的 探讨保乳手术加综合治疗乳腺癌的手术适应证、治疗方法和疗效。方法 对 46例I～IIb 期乳腺癌施行保乳手术加术后放疗、化疗及内分泌治疗等综合治疗 (保乳组 ) ;并与同期施行改良根治术加综合治疗的 5 0例I～IIb 期乳腺癌 (对照组 )进行对比。两组患者术后均随访 0 .5～ 14年 ,平均 4年。结果 保乳组 46例双侧乳房乳头基本对称、外形丰满 ,外观优良。保乳组、对照组的平均手术时间分别为 (14 3 .7± 2 1.6)min ,(181.9± 16.0 )min ;术中平均出血量分别为 (2 42± 73 )ml ,(3 76± 5 6)ml ,手术并发症率分别为 15 .2 %,3 4.0 %;保乳组均优于对照组 (均P <0 .0 5 )。保乳组 3 ,5 ,10年期生存率分别是 96.8%,88.9%,85 .7%,总局部复发率是 6.5 %;对照组 3 ,5 ,10年期生存率分别是 97.1%,89.5 %,87.5 %,总局部复发率是 4.0 %。两组生存率和复发率比较差异无显著性(均P >0 .0 5 )。结论 临床早期乳腺癌采用保乳手术加综合治疗可以取得满意的临床疗效 ,可作为早期乳腺癌的首选治疗方法。
Objective To study the surgical indication ,the operative procedure and effect for the patients with breast cancer (BC). Methods Forty-six cases of stage I～II bBC were treated with breast-conserving surgery plus radiotherapy ,chemotherapy and endocrinetherapy postoperativly .The effect of breast-consering group was compared with BC patient (50 casesI～II b) treated by modified radical mastectomy only (comtrol group) . All cases in both aroups were followed-up for 0.5～14 years with average 4 years . Results The patients treated by breast-conserving surgery had good cosmesis effect than that in control group patients did.The 3、5、10 year′s survival rate and local recurrence were 96.8%,88.9%, 87.5 % and 6.5% in breast-conserving surgery group,and 97.1%,89.5%, 87.5 % and 4.0% in modified radical mastectomy group, respectively (all P >0.05) . Conclusions The effect of early-stage of breast cancer treatment by breast-conserving therapy plus other adjunct therapies is satisfactory . It can be as the first choice for the treatment of patients with early-stage of breast cancer.
出处
《中国普通外科杂志》
CAS
CSCD
2004年第5期327-330,共4页
China Journal of General Surgery
基金
广西柳州地区地厅级科技攻关项目 (2 0 0 1 0 4 0 5)
关键词
乳腺肿瘤/外科学
保乳手术
BREAST NEOPLASMS/surg
BREAST-CONSERVIGN SURGERY
