摘要
本文应用免疫组织化学技术(ABC法),用人肺癌单克隆抗体(HLC_3-AB)标记186例脑转移瘤。分成两组:原发灶明确组59例,原发灶未明确组127例。在原发灶明确组中的肺癌脑转移者36例中,有33例(91.7％)呈现HLC_3-AB阳性;而其他癌肿脑转移者23例中,只有2例(8.7％)呈现HLC_2-AB弱阳性,两者有显著差异。在原发灶未明确组的127例中,共有68例呈现HLC_3-AB阳性反应。全组186例脑转移瘤中,共有101例呈现HLC_3-AB阳性反应(占53.5％)。在脑转移性腺癌125例中,对HLC_3-AB呈阳性反应者为76例(占61％)。本文结果证明肺癌是神经外科手术切除的脑转移瘤的重要原发灶。并对单克隆抗体HLC_3-AB的特异性、脑转移性肺癌的频率及其转移途径作简短讨论。
By using the immunohistochemical technique(ABC method), 186 cases of cerebralmetastatic tumors labeled with McAb against human lung carcinoma were reported.They were divided into two groups: primary site determined group and undeterminedgroup. In determined group(59 cases), 33/36 cases (91.6%) of lung carcinomas showedHLC_3 positive reactions, but among 23 cases of other cancers, only two cases showedweak positive reactions. This result indicated that the HLC_8 have strong specificreaction to the lung carcinomas. In undetermined group (127 cases), 68 cases ofmetastatic tumors reacted to HLC_8 positively.
出处
《肿瘤》
CAS
CSCD
北大核心
1992年第6期265-266,257,共3页
Tumor
