摘要
目的 : 探讨特应性皮炎 (AD)皮损微生物定植情况 ,为临床合理选用抗菌药物有效控制该病提供依据。方法 : 无菌生理盐水浸湿的棉拭子于 4 3例AD患者皮损处取标本 ,同时对 39例患者非皮损处及 10例健康人取标本作对照 ,进行细菌培养及菌落计数 ,金葡菌予常规药敏试验。结果 : AD患者皮损细菌阳性率为 74 .4 2 % ,金葡菌为主要的致病菌 ,占 6 5 .6 3% ;非皮损处也可分离出细菌 ,但金葡菌阳性率及密度均明显低于皮损处 (P <0 .0 0 1)。结论 : 微生物感染因素 ,尤其金葡菌感染或定植 。
Objective: To determine the colonizing feature of bacteria in lesions of atopic dermatitis (AD), in order to provide the basis for the rational use of antimicrobial agents clinically.Methods: Samples were obtained from the lesions and normal skin in AD patients with detergent scrub technique. Staphylococcus aureus were examined by culture and quantitative assessment of the density and microbial sensitivity tests. Results: The culturally positive rate of bacterial colonization was 74.42% on the skin lesions of AD, and S. aureus was overwhelmingly the dominant species accounting for 65.63%. Bacteria were also isolated from the normal skin in these patients. However, the positive rate and the density of S. aureus colonization were much higher in skin lesions compared to normal skin (P<0.001). Conclusion: S. aureus may play an important role as an aggravating factor in pathogenesis of AD.
出处
《中国麻风皮肤病杂志》
北大核心
2004年第2期110-112,共3页
China Journal of Leprosy and Skin Diseases
