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caspase在疾病与组织损伤中的作用 被引量：2

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摘要 半胱氨酸天冬氨酸特异性蛋白酶(cysteinyl aspartate specific proteinase),简称caspase,由14个家族成员组成(caspase-1～caspase-14).这类蛋白酶与细胞凋亡形态学特征变化(如胞膜空泡形成、核膜裂解、染色质聚集和边聚及DNA断裂等)以及一些生化改变关系密切[1].而细胞凋亡在正常情况下是生理性的自我消亡过程,在胚胎的发育,生物体内环境稳态的维持以及多细胞对外来和内在伤害方面的防御均起着非常重要的作用.而凋亡过程的紊乱可能与许多疾病发生有直接或间接的关系,如肿瘤、自身免疫性疾病、退行性神经病变及局部损伤等[2].
作者 赵锐 官大威 杜宇
机构地区 中国医科大学法医学院
出处 《中国法医学杂志》 CSCD 2004年第1期58-60,共3页 Chinese Journal of Forensic Medicine
基金 国家自然科学基金资助项目(30271347) 教育部留学归国基金资助项目(教外留司[2000]367号)
关键词 CASPASE 组织损伤 细胞凋亡 蛋白酶 细胞形态学 病理学
分类号 D919 [医药卫生—法医学]
  • 相关文献

参考文献23

  • 1Thornberry NA, Bull HG, Calaycay JR, et al. A novel heterodimeric systeine protease is required for interleukin-1βprocessing in monocytes [ J]. Nature, 1992, 356 (6372):768 - 774.
  • 2Thompson CB. Apoptosis in the pathogenesis and treatment of disease [J]. Science, 1995, 267 (15203):1456-1462.
  • 3Thornberry NA, Lazebnik Y. Caspases: enemies within[J]. Science, 1998, 281 (5381): 1312-1316.
  • 4Vincenz C, Dixit VM. Fas-associated death domain protein interleukin-1 β-converting enzyme 2 ( FLICE2 ), an ICE/CED-3 homologue, is proximally involved in CD95 and p55-mediated death signaling [ J ]. J Biol Chem. , 1997, 272(10): 6578 -6583.
  • 5Seki K, Yoshikawa H, Shiiki K, et al. Cisplatin (CDDP)specifically induces apoptosis via sequential activation of caspase-8, -3 and-6 in osteosarcoma [ J ]. Cancer Chemother Pharmacol, 2000, 45 (3): 199 -206.
  • 6Turuner N, Paakko P, Soini Y. Apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspase-3, -6, -8 and apoptosis regulating protein bcl-2 and Bax [J]. Histol Histopathol, 2000, 15 (1): 53 -60.
  • 7Cicala C, Arthos J, Rubbert A, et al. HIV-1 envelope induces activation of Caspase-3 and cleavage of focal adhesion kinase in primary human CD+4 T cells [J]. Proc Natl Acad Sci, 2000, 97 (3): 1178 -1183.
  • 8Huang JQ, Radinovic S, Rezaiefar P, et al. In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia [ J ]. Eur J Pharmacol, 2000, 402(1-2): 139 -142.
  • 9Kawasaki M, Kuwano K, Hagimoto N, et al. Protection from lethal apoptosis in lipopolysaccharide-induced acute injury in mice by a caspase inhibitor [ J ]. Am J Pathol, 2000, 157(2): 597 - 603.
  • 10Fink KB, Andrews LJ, Butler WE, et al. Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade [ J]. Neurosci, 1999, 94(4): 1213 - 1218.

二级参考文献17

  • 1David G. Greenhalgh. The role of apoptosis in wound healing[J]. Int J Biochem Cell Biol, 1998, 30:1019.
  • 2Potthoff A, Ledig S, Martin J, et al. Significance of the caspase family in Helicobacter pylori induced gastric epithelial apoptosis [J]. Helicobacter, 2002, 7 (6): 367.
  • 3Singh AB, Kaushal V; Megyesi JK, et al. Cloning and expression of rat caspase-6 and its localization in renal ischernia/reperfusion injury [J]. Kidney Int, 2002, 62 (1): 106.
  • 4Guan DW, Ohshima T and Kondo T. Expression of Fas and FasL during the skin wound healing process in mice [ J ]. Histoechem J, 2000, 32:85.
  • 5Savitz SI,Rosenbaum DM.Apoptosis in neurological disease[].Neurosurgery.1998
  • 6Marmarou A,Foda MAA,Brink WVD,et al.A new model of diffuse brain injury in rats.Part 1. Pathophysiology and biomechanics[].Journal of Neurosurgery.1994
  • 7Chen J,Nagayama T,Jin KL,et al.Induction of Caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia[].The Journal of Neuroscience.1998
  • 8Flaws JA,Kugu K,Alexander M,et al.Interleukin-1β-converting enzyme-related proteases (IRPS) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle[].The Journal of Endocrinology.1995
  • 9Gillardon F,Bottiger B,Schmitz B,et al.Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy[].Molecular Brain Research.1997
  • 10Cohen GM.Capases: the executioners of apoptosis[].Biochemical Journal.1997

共引文献44

同被引文献11

  • 1肖延风,刘雅,田玮,任利芬.Survivin在白血病中表达及其与Caspase、Fas相关性研究[J].实用儿科临床杂志,2005,20(1):13-15. 被引量：17
  • 2陈凤超,陈言汤.病理性瘢痕组织中肿瘤坏死因子受体1和半胱氨酸蛋白酶3对成纤维细胞凋亡的调控[J].中国临床康复,2005,9(2):138-139. 被引量：9
  • 3Susin SA,Zamzami N,Castedo M,et al.The central executioner of apoptosis:multiple connections between protease activation and mitochondria in Fas/Apo-1/CD95 and ceramide-induced apoptosis[J].J Exp Med,1997,186(1):25
  • 4Cicala C,Arthos J,Rubbert A,et al.HIV-1 envelope induces activation of Caspase-3 and cleavage of focal adhesion kinase in primary human CD4 T cell[J].Proc Natl Acad Sci,2000,97(3):1178
  • 5Greenhalgn DG.The role of apoptosis in wound healing[J].Int J Bioehem Cell Biol,1998,30(9):1019-1030.
  • 6Guan DW,Ohshima T,Kondo T.Immunohistochemistrystudy on Fas and Fas ligand in skin wound healing[J].Histochem J,2000,32(2):85-91.
  • 7Cousin F,Baldassini S,Bourchany D,et al.Expression of the pro-apoptotic caspase 3/CPP32 in cutaneous basal and squamous cell carcinomas[J].J Cutan Pathol,2000,27(5):235-241.
  • 8Boulakia CA,Chen G,Ng FW,et al.Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-fibose) polymerase[J].Oncogene,1996,12:529-535.
  • 9Chandler JM,Cohen GM,MacFadane M.Differentsubcellutar distribution of caspase-3 and caspase-7following Fas-induced apoptosis in mouse liver[J].JBiol Chem,1998,273(18):10815-10818.
  • 10杜宇,官大威,赵锐.小鼠皮肤切创愈合过程中caspase-6、-7表达的免疫组织化学研究[J].中国法医学杂志,2003,18(5):259-261. 被引量：8

引证文献2

二级引证文献9

中国法医学杂志
2004年 第1期

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