期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Effect of antisense oligodeoxynucleotide of telomerase RNA on telomerase activity and cell apoptosis in human colon cancer 被引量：11

Effect of antisense oligodeoxynucleotide of telomerase RNA on telomerase activity and cell apoptosis in human colon cancer
暂未订购
导出
摘要 AIM:To explore the effect of antisense oligocleoxynucletide(As-ODN)of telomerase RNA on telomerase activity and cell apoptosis in human colon cancer.RESULTS:The telomerase activity in SW480 cells transfected with 1.0μmol/L of As-ODN for 2-5days,was significantly decreased in a time-dependent manner,and the cells underwent apoptosis.The missense ODN(Ms-ODN)and the control group transfected with SW480 cells did not show these changes.CONCLUSION:As-ODN can specifically inhibit the telomerase activity of SW480 cells and induce apoptosis.
作者 Ying-An Jiang He-Sheng Luo Li-Fang Fan Chong-Qing Jiang Wei-Jin Chen
机构地区 Department of Gastroenterology Department of Pathology Department of General Surgery Department of Medical Information
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第3期443-445,共3页 世界胃肠病学杂志(英文版)
基金 Supported by the Science and Technology Research Project of Hubei Province,No.2002AA301C72
反义寡核苷酸 端粒酶 细胞凋亡 结肠癌 酶联免疫吸附法 基因疗法
分类号 R735.35 [医药卫生—肿瘤]
  • 相关文献

参考文献1

二级参考文献32

  • 1Dahsc R, Ficdler W, Error G. Telomeres and telomerase: biological and clinical importance. Clin Chem 1997; 43:708-714.
  • 2Yan P,Coindre JM,Benhattar J,Bosman FT,Guillou L.Telomerase activity and human telomerase reverse transcriptase mRNA exprsssion in soft tissue tumors: correlation with grade, histology,and proliferative activity. Cancer Res 1999; 59:3166-3170.
  • 3Feng J, Funk WD, wang SS, Weinrich SL, Avilion AA, Chiu CP,Adams RR, Chang E, Allsopp RC, Yu J. The RNA component ofhuman telomerase. Science 1995: 269:1236-1241.
  • 4Norton JC, Piatyszek MA, Wright WE, Shay JW, Corey DR. Inhibition of human telomerase activity by peptide nucleic acids. Nat Biotechnol 1996; 14:615-619.
  • 5Harrington L, Mcphail T, Mar V, Zhou W, Oulton R, Bass MB,Arruda I, Robinson MO. A mammalian telomerase-associated protein. Science 1997: 275:97.~,-977.
  • 6Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F.TLPI: a gene encoding a protein component of mammali telomerase is a novel member of WD repeats family. Cell 1977; 88:875-884.
  • 7Nakamura TM,Morin GB,Chapman KB,Weinrich SL,Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and humarL Science 1997; 277:955-959.
  • 8Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P,Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q,Bacchetti S, Haber DA, Weinberg RA. hEST2, the putative human telomerase catalytic subun gene, is up-regulated in tumor cells and during immortalization. Cell 1997; 90:785-795.
  • 9Kilian A, Bowtell DD, Abud HE, Hime GR, Venter DJ, Keese PK Duncan EL, Reddel RR, Jefferson RA. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing pattern in different cell types. Hum Mol Genet 1997;6:2011-2019.
  • 10Blasco MA, Funk W, Villeponteau B, Greider CW. Functional characterization and developmental regulation of mouse telomerase RNA. Science 1995; 269:1267-1270.

共引文献14

同被引文献31

引证文献11

二级引证文献23

World Journal of Gastroenterology
2004年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部