摘要
作为一种多基因疾病 ,冠心病是由遗传和环境因素共同作用的结果 ,在许多国家是主要的死因之一。由于目前冠心病的发病机制尚不十分清楚 ,阻碍了其易感基因的定位分离研究。冠心病遗传因素的确定 ,显然将有助于其易感基因定位分离研究。迄今除发现了个别的相关基因外 ,绝大部分的遗传易感性相关基因尚未被发现 ,其研究仍然存在许多问题。为此 ,本文就其易感基因可能的研究策略和方法作一综述。这些方法同样也适用于诸如中风、外周血管阻塞、高血压。
Coronary heart disease (CHD) is a leading cause of death for adults in many countries. It is multifactorial in origin with both genetic and environmental factors contributing to its development. But the molecular basis of CHD pathogenesis remains obscure, which represents a major obstacle to the identification of CHD susceptibility genes. Knowledge of genetic factors contributing to the pathogenesis of CHD will undoubtedly advance efforts to identify CHD susceptibility genes. The benefits promised are great, but progress to gene identification in CHD has been rather disappointing so far. This review aims to discuss the current and future approaches to gene discovery in CHD. And these approaches can be applied equally to other multifactorial traits in the cardiovascular arena - stroke, peripheral arterial occlusive disease, hypertension, heart failure and beyond.
出处
《生理科学进展》
CAS
CSCD
北大核心
2004年第2期130-134,共5页
Progress in Physiological Sciences
基金
国家 8 6 3计划 (2 0 0 1AA2 2 4 0 2 1
2 0 0 2BA711A10 )资助课题
关键词
冠心病
基因
筛选
遗传
单核苷酸多态性
Coronary heart disease
Gene
Single-nucleotide polymorphism
