摘要
目的 研究封闭负压引流技术 (VAC)对急性创面愈合的影响 ,探讨其可能的治疗机制。方法 以免耳背急性全层皮肤缺损创面为模型 ,选取左侧耳背的创面为治疗组 ,给予封闭负压引流治疗 ;右侧创面为对照组 ,给予常规油纱敷料包扎治疗。分别在创面形成即刻和第 3、6、9天给创面摄影 ,应用图像分析软件计算创面愈合率。另外切取各时间点创面标本进行组织形态学观察。结果 在创面形成第 6天和第 9天 ,VAC组愈合率均高于对照组 ,两者差异有非常显著性 (P <0 .0 1)。组织形态学观察可见VAC组创面炎症反应较轻 ,肉芽组织生长和再上皮化速度均较对照组快。结论 封闭负压引流技术能减轻创面炎症反应 ,加快肉芽组织生长和再上皮化速度 ,显著促进兔耳背急性创面愈合。
Objective To explore the effects of vacuum-assisted-closure (VAC) technique on the repair of acute wounds to find the possible theraeutic mechanism.Methods Acute whole-skin-loss wounds were formed on rabbits' ears and divided into two groups:one under the VAC treatment and the other under the common gauze treatment.Pictures were taken right after the wounds were formed and on the 3rd,6th and 9th day,and Graphics Analysis tool was used to account the healing rate of both groups.Histochemistry technique was also used to observe the histological changes during the process.Results Healing rate of the VAC-treated group was higher than that of the control group on both the 6th and 9th days,and the difference was significant ( P <0.01).The VAC-treated wounds also showed less severe inflammation and higher velocity of formation of granulation tissue and reepithelization.Conclusion VAC technique can effectively control inflammation and expedite the formation of granulation tissue and reepithelization of acute wounds,so significantly promote the wounds to repair.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2004年第1期35-36,共2页
Chinese Journal of Experimental Surgery
