摘要
从缬氨酸,L-丝氨酸,L-苏氨酸,L-异亮氨酸出发合成了海洋环肽Ascidiacy-clamide的异构体cyclo-[-D,L-(Val)Thz-L-Ser-L-Ile-D,L-(Val)Thz-L-Thr-L-Ile-]-。其中噻唑氨基酸由Hantzsch方法合成,肽链由DCC-HOBT(DCC即二环己基碳化二亚胺,dicyclohexylcarbodimide;HOBT即1-羟基合水苯并噻唑,1-hydroxybenzotria-zolenydrate)缩合而形成。关大环采用叠氮方法。
The cyclopeptide DL-(Val)T hz-L-Ser-L-Ile L-Ile-L-Thr-DL-(ValThz,an isomer of marine cyclopeptide Ascidiacyclamide has been synthesized. The rhiazole amino acid was prepared by Hantzsch method. The peptide bonds were constructed by DCC-HOBT coupling method and the peptide ring was formed by azide method.
出处
《中山大学学报（自然科学版）》
CAS
CSCD
1992年第2期57-61,共5页
Acta Scientiarum Naturalium Universitatis Sunyatseni
关键词
肽类
异构体
海洋
抗肿瘤活性
cyclopeptide
thiazole
antineoplastic activity
synthesis
