摘要
合成并表征了3种在苯环上具有推电子或拉电子取代基的新的不对称四苯基卟啉衍生物及其铁配合物。研究了其铁配合物作为细胞色素P450模拟酶对环己烷的羟化作用,并与结构类似的对称卟啉进行了比较。结果进一步证明,与对称金属卟啉相似,苯环上取代基性质和空间位阻对于金属卟啉的催化活性是十分重要的。不对称金属卟啉的催化活性比结构类似的对称金属卟啉的稍大。
Three new asymmetrical derivatives of tetraphenylporphyrin with electron-donating and electron-withdrawing substituents in its phenyls and their iron(Ⅲ) coordination compounds have been synthesized and characterized. The hy-droxylation of cyclohexane by these asymmetrical porphyrinatoiron(Ⅲ) chloride as
model enzymes of cytochrome P450 have been studied and compared with some an-alogue symmetrical porphyrinatoiron(Ⅲ) chloride. It has been further proved that properties and steric effect of the substituents in phenyl of porphyrins are important for catalytic activility similar to symmetrical metalloporphyrins. It seems
that the catalytic activility of the asymmetrical metalloporphyrins is slightly greater than the symmetrical ones with analogue construction.
出处
《中山大学学报（自然科学版）》
CAS
CSCD
1992年第1期52-59,共8页
Acta Scientiarum Naturalium Universitatis Sunyatseni
基金
国家自然科学基金
英国皇家化学会会员研究基金
关键词
卟啉
铁
细胞色素
环己烷
羟化
asymmetrical porphyrin
derivatives of tetraphenylporphyrin
model of cytochrome P450
cyclohexane
hydroxylation
