摘要
目的:观察未抗病毒治疗的慢性乙型肝炎病毒(HBV)感染者体内病毒载量的变化及其动力学特征。方法:采用荧光定量PCR方法对未进行抗病毒治疗的3例不同临床表型的慢性HBV感染者血清HBV载量进行连续监测,同时测定每一时相点的血清ALT和总胆红素. 结果:不管是间隔1 d、1wk还是1mon,3例慢性HBV 感染者体内HBV DNA水平均存在自发波动,且与血清ALT和总胆红素变化相关性不确定. 结论:3例慢性感染者体内HBV载量的自然波动表现出一定的模式特征.我们提出—种宿主对病毒负反馈控制的PID 模式,以期对持续性病毒感染的体内生态演化作出评价和预测.
AIM: To observe the variation of viral load and characteristics of within-host dynamics in patients with chronic hepatitis B virus infection without receiving antiviral therapy. METHODS: Serum was collected consecutively from 3 patients with different clinical phenotype, ALT and total bilirubin were determined, and HBV DNA was measured by quantitative TaqMan fluorogenic PCR. RESULTS: Spontaneous fluctuations of HBV DNA load were observed when measured daily, weekly and monthly in our untreated patients with chronic HBV infection, but there was no determinate correlation between HBV DNA loads and ALT values. CONCLUSION: The spontaneous fluctuation of viral load in untreated patients with different clinical phenotype displays some characteristic patterns. Here we propose a PID pattern for host feedback to virus using population quantity of HBV as variant, which may be used for the prediction of virus-host ecological evolution in persistent HBV infection.
出处
《世界华人消化杂志》
CAS
2004年第4期862-865,共4页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30200234
No.10101029~~
