摘要
我们研究了烧伤病人营养摄入中脂肪这一要素对烧伤后免疫功能的调节作用。在摄入总脂肪量较低时,鱼油(n-3多价不饱和脂肪酸)摄入能改善烧伤病人的淋巴细胞转化功能并增加 IrgG 类抗体的产生。摄入总脂肪量较高时,鱼油摄入对烧伤后免度功能没有保护作用。其机制和鱼油可抑制烧伤后花生四烯酸代谢过激,从而能降低前列腺素 E_2有关;高脂肪摄入对烧伤后免疫功能有不利影响的原因可能涉及其它能导致淋巴细胞膜液性下降等因素。
Since fatty acids influence prostaglandins synthesis,and both fatty acids and prostag- glandins modulate immune function,we studied the effects of dietary fats on immunomo- dulation in severely burned patients.We observed that the administration of fish oil can affect immune response after burns,but a high fat intake seemed to markelly reduce the effect.With lower fat intake,fish oil induced a higher mitogenic response of the lymphocyte to PHA and higher blood IgG level in burned patients. These findings suggest that regulation of dietary lipids may play an important role in nutritional support after burn injury.
