摘要
用日立835-50型氨基酸自动分析仪测定合并败血症和无败血症的烧伤病人血浆游离氨基酸含量。两组比较,败血症病人苯丙/酪氨酸(Phe/Tyr)升高,14和21天升高显著;支链氨基酸/芳香氨基酸(BCAA/AAA)比值降低,14天显著;脯氨酸3和7天升高显著。提示:发生败血症时代谢紊乱加重,影响预后。
The sequential changes in plasma free amino acid concentration were analyzed and compared in burned patients with sepsis (n=12) and without sepsis (n=19).After burn injury,phenylalanine,methionine,lysine,and the Phe/Tyr ratio were significantly inc- reased in two groups (P<0.05～0.01).Threonine,serine,histidine,arginine,proline and BCAA/AAA ratio were significantly decreased intwo groups (P<0.05～0.001).The Phel Tyr ratio in patients with sepsis was much higher than that in patients without sepsis on postburn days 14 and 21 (P<0.05),while the BCAA/AAA ratio in patients with sepsis was much lower than that in patients without sepsis on postburn day 14 (P<0.01).The level of proline in patients with sepsis was much higher than that in patients without sepsis on postburn days 3 and 7 (P<0.05).It is suggested that these results,in collaboration with other clinical and laboratory findings,may be helpful in foretelling the probable develop- ment of sepsis in patients with major burns.
