摘要
目的:探讨序贯应用联合化疗与α干扰素治疗急性髓细胞白血病细胞凋亡比率的变化以及这种变化与完全缓解(CR)之间的关系。方法:对22例接受两个疗程联合化疗与α干扰素序贯治疗的治疗组以及23例只接受两个疗程联合化疗的急性髓细胞白血病(AML)的对照组患者进行了对比观察。结果:治疗组治疗前凋亡比率0.0487±0.0430,第一疗程后凋亡比率0.2522±0.0849,第二疗程后凋亡比率0.3253±0.0918;对照组治疗前凋亡比率0.0491±0.0440,第一疗程后凋亡比率0.1845±0.0812,第二疗程后凋亡比率0.2580±0.1127。两组比较第一疗程(t=2.733,P=0.009)及第二疗程(t=2.188,P=0.0350)细胞凋亡比率皆有显著性差异。治疗组中第一疗程CR19例(86%),第二疗程CR20例(90%);对照组中第一疗程CR11例(48%),第二疗程CR14例(61%)。两组比较第一疗程CR(字2=7.515,P=0.006)及两个疗程累计CR(字2=5.494,P=0.019)均有显著差异。结论:序贯治疗后细胞凋亡比率以及完全缓解率有较大提高。
Objective: To analyze the change of ratio of apoptosis of cell of AML which had treat with chemotherapy and α interferon as well as this kind relation between changing and complete remission (CR). Methods: Ratio of apoptosis and CR of 22 cases which had treat with chemotherapy and α interferon (group 1) and 23 cases which had treat only with chemotherapy (group 2) are analyzed Results: Ratio of apoptosis in group 1: before treatment 0.0487±0.0430, after first course 0.2522±0.0849, cumulate one after second course 0.3253±0.0918 ; ratio of apoptosis in group 2: before treatment 0.0491±0.0440, after first course 0.1845±0.0812, cumulate one after second course 0.2580±0.1127. ratio of apoptosis in first course (t=2.733, P=0.009) and second course (t=2.188, P=0.0350) had significant difference between group 1 and group 2. CR in group 1: had 19 cases(86%)after first course, had cumulate 20 ones (90%) after second course. CR rate in first course (?字2=7.515, P=0.006) and cumulate CR rate in second course(?字2=5.494, P=0.019) had significant difference between group 1 and group 2. Conclusion: Ratio of apoptosis and CR rate had an increase after treatment with chemotherapy and α interferon.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2004年第6期312-314,共3页
Chinese Journal of Clinical Oncology
基金
广东省医学科研基金资助(编号:A1999602)
关键词
急性髓细胞白血病
联合化疗
Α干扰素
完全缓解
细胞凋亡
Acute myelocytic leukemia Combination chemotherapy Interferon-a Complete remission Apoptosis
