摘要
目的 探讨IgA肾病患者预后的影响因素。方法 对 1984 .6 - 2 0 0 0 .12间经肾活检证实为IgA肾病患者 86例住院和随访资料进行分析。结果 86例患者中 4例男性在随访结束时发生尿毒症 ,病程 (115 .9±3.2 )月。年龄≥ 4 5岁组、肾小球硬化组、间质存在纤维化组、肾小管萎缩组患者内生肌酐清除率 (Ccr)在肾穿刺和随访结束时均分别显著低于 <4 5岁组 ;高血压组肾穿刺时Ccr与无高血压患者无显著差别 ,而随访结束时则显著低于无高血压组。多因素逻辑回归分析显示年龄和肾小管萎缩是影响IgA肾病预后的主要因素。 结论 性别、年龄、高血压、肾小球硬化程度、肾小管萎缩及间质纤维化是影响IgA肾病预后不良的重要因素 。
Purpose: To determine the factors which affect prognosis of immunoglobulin A nephropathy (IgAN). Methods: Eighty six patients of IgAN from 1984.6-2000.12 were followed up in the study and the diagnosis of all patients was confirmed by renal biopsy. Results: Four patients suffered from uremia by the end of follow-up, all of them were man and the duration of disease was (115. 9 ± 3. 2) months. At the end, 2 patients received hemodialysis, 1 patient received renal transplantation and another patient was treated by conservative drug. Endogenous creatinine clearance (Ccr) was significantly lower in the group of age≥45 years, glomerulosclerosis, interstitial fibrosis, renal tubule atrophy than that in the group of age<45 years, no glomerulosclerosis, no interstitial fibrosis and no renal tubule atrophy, respectively at time of renal biopsy and at the end of follow-up. Ccr in the hypertension group was similar to that in normal blood pressure group at time of renal biopsy, but at the end of follow-up Ccr in the former group was lower than that in the later group. Age and renal tubule atrophy were the important factors which affected the patients prognosis by the analysis of logistic regression method. Conclusions: The factors related to the prognosis of IgAN include sex, age, hypertension, glomerulosclerosis, interstitial fibrosis and renal tubule atrophy, among them age and renal tubule atrophy are the major factors.
出处
《复旦学报（医学版）》
EI
CAS
CSCD
北大核心
2004年第2期191-194,共4页
Fudan University Journal of Medical Sciences
关键词
IGA肾病
预后
影响因素
多元回归分析
Biopsy
Drug products
Patient monitoring
Risk assessment
Transplantation (surgical)
