摘要
目的 体外定量研究几种治疗银屑病、寻常痤疮药物的抗白细胞趋化活性。方法 采用琼脂糖平板法观察药物对甲酰三肽 (fMLP)诱引的WBC移动距离的影响。结果与结论 受试药中 :丙酸氯倍他索 (CP)、全反式维A酸(RA)、蒽林 (ATL)、雷公藤内酯醇 (T0 )、四环素 (TE)、氧氟沙星 (OF)、盐酸克林霉素 (CL )、氯霉素 (CHLO)、CP+RA和CL +RA对人WBC趋化性有不同程度的抑制作用 ,且量 -效关系显著。抑制WBC趋化活性的IC5 0 值分别为 0 .78,9.69,1.0 5,8.5× 10 - 4,9.89,2 .59,8.2 7,0 .2 7和 4.57μg/ml。CHLO和环孢素A (CyA)
Objective To evaluated the effects of some an ti-psoriatic and anti-acne agents on chemotactic activity of human WBC quantit atively in vitro.Methods The distances of moving of WBC directed by fMLP i n argarose gel were observed by microscopy.Results and Conclusion Chemotactic activities of WBC wer e inhibited by CP,RA,ATL,T 0,TE,OF,CL,CHLO,CP+RA and CL+RA.The IC 50 value s were 0.78,9.69,1.05,8.5×10 -4 ,9.89,2.59,8.27,0.27 and 4.57μg/ml,respect ively.The same effects of CHLO and CyA in pharmacological concentration were not been find.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2003年第6期377-378,共2页
The Chinese Journal of Dermatovenereology
