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MUC5AC蛋白在大肠肿瘤中的表达及意义 被引量：2

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摘要 目的:探讨大肠肿瘤组织中MUC5AC蛋白的表达情况及其意义.方法:采用S-P免疫组化法对10例正常大肠黏膜及60例大肠肿瘤石蜡包埋标本中MUC5AC蛋白的表达进行了检测,PBS代替一抗作为阴性对照.结果:正常大肠黏膜几乎不表达MUC5AC蛋白.肿瘤组织中MUC5AC的总阳性率为46.67%(28/60),其中,大肠腺瘤(100%,10/10)与印戒细胞癌(70%,7/10)中表达率较高,与高、中、低分化的腺癌及黏液腺癌相比,MUC5AC的表达具有显著性差异(P<0.05).结论:MUC5AC表达的异常变化可能是大肠肿瘤发生过程中的早期事件.
作者 卜晓东 李俐 黄培林 樊克武 赵建华
机构地区 东南大学基础医学院病理教研室 南京市第一医院病理科
出处 《世界华人消化杂志》 CAS 2004年第2期467-469,共3页 World Chinese Journal of Digestology
关键词 MUC5AC蛋白 大肠肿瘤 基因表达 肠黏膜 黏液腺癌
分类号 R735.34 [医药卫生—肿瘤]
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参考文献15

  • 1Myerscough N, Sylvester PA, Warren BF, Biddolph S, Durdey P, Thomas MG, Carlstedt I, Corfield AP. Abnormal subcellular distribution of mature MUC2 and de novo MUC5AC mucins in adenomas of the rectum: immunohistochemical detection using non-VNTR antibodies to MUC2 and MUC5AC peptide. Glycoconj J 2001;18:907-914.
  • 2Sylvester PA, Walsh M, Myerscough N, Warren BF, Corfield AP, Thomas MG, Durdey P. Mucin gene expression in the ileoanal reservoir is altered and may be relevant to the risk of inflammation and dysplasia. Gut 2002;51:386-391.
  • 3Lee MJ, Lee HS, Kim WH, Choi Y, Yang M. Expression of mucins and cytokeratins in primary carcinomas of the digestive system. Mod Pathol 2003;16:403-410.
  • 4Longman RJ, Douthwaite J, Sylvester PA, O'Leary D, Warren BF, Corfield AP, Thomas MG. Lack of mucin MUC5AC field change expression associated with tubulovillous and villous colorectal adenomas. J Clin Pathol 2000;53:100-104.
  • 5Nollet S, Forgue-Lafitte ME, Kirkham P, Bara J. Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors, lnt J Cancer 2002:99:336-343.
  • 6Sylvester PA, Myerscough N, Warren BF, Carlstedt I, Corfield AP, Durdey P, Thomas MG. Differential expression of the chromosome 11 mucin genes in colorectal cancer. J Pathol 2001;195:327-335.
  • 7Baldus SE, Hanisch FG, Putz C, Flucke U, Monig SP, Schneider PM, Thiele J, Holscher AH, Dienes HP. Immunoreactivity of Lewis blood group and mucin peptide core antigens: correlations with grade of dysplasia and malignant transformation in the colorectal adenoma-carcinoma sequence. Histol Histovathol 2002;17:191-198.
  • 8Kocer B, Soran A, Erdogan S, Karabeyoglu M, Yildirim O,Eroglu A, Bozkurt B, Cengiz O. Expression of MUC5AC in colorectal carcinoma and relationship with prognosis. Pathol Int 2002;52:470-477.
  • 9Perrais M, Pigny P, Copin MC, Aubert JP, Van Seuningen I.Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and spl. J Biol Chem 2002;277:32258-32267.
  • 10Kohri K, Ueki IF, Shim JJ, Burgel PR, Oh YM, Tam DC, Dao-Pick T, Nadel JA. Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor. Eur Respir J 2002;20:1263-1270.

同被引文献21

  • 1安锦丹,王静芬,赵宇,董德武.粘蛋白MUC5AC在原发性和转移性卵巢肿瘤中的表达及意义[J].哈尔滨医科大学学报,2005,39(6):498-501. 被引量：1
  • 2Boonla C, Wongkham S, Sheehan JK, Wongkham C, Bhudhisawasdi V, Tepsiri N, Pairojkul C. Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma. Cancer 2003; 98: 1438-1443
  • 3Wakatsuki K, Yamada Y, Narikiyo M, Ueno M, Takayama T, Tamaki H, Miki K, Matsumoto S, Enomoto K, Yokotani T, Nakajima Y. Clinicopathological and prognostic significance of mucin phenotype in gastric cancer. J Surg Oncol 2008; 98:124-129
  • 4Yu CJ, Shih JY, Lee YC, Shun CT, Yuan A, Yang PC. Sialyl Lewis antigens: association with MUC5AC protein and correlation with post-operative recurrence of non-small cell lung cancer. Lung Cancer 2005; 47:59-67
  • 5Aishima S, Kuroda Y, Nishihara Y, Taguchi K, Iguchi T, Taketomi A, Maehara Y, Tsuneyoshi M. Down-regulation of aquaporin-1 in intrahepatic cholangiocarcinoma is related to tumor progression and mucin expression. Hum Pathol 2007; 38:1819-1825
  • 6Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev 1999; 13:3191-3197
  • 7Elbashir SM, Martinez J, Patkaniowska A, Lendeckel W, Tuschl T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J 2001; 20:6877-6888
  • 8Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391:806-811
  • 9Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 2000; 47:589-594
  • 10Wittel UA, Goel A, Varshney GC, Batra SK. Mucin antibodies - new tools in diagnosis and therapy of cancer. Front Biosci 2001; 6: D1296-D1310

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世界华人消化杂志
2004年 第2期

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