反义寡聚核苷酸的化学修饰
Chemical Modification of Antisense Oligonucleotide
摘要
反义寡聚核苷酸(antisense oligonucleotides, AS-ODNs)的概念最先提出于1967年,经过30多年的研究,人们已意识到在各种反义寡聚核苷酸的广阔领域里,有可能寻找到更有效的抗病毒和抗肿瘤新药.
出处
《上海第二医科大学学报》
CSCD
2003年第3期285-288,共4页
Acta Universitatis Medicinalis Secondae Shanghai
参考文献21
-
1Burkhard J, Uwe ZW. Antisense therapy for cancer-the time of truth [J]. Lancet, 3:672-683.
-
2Tamm I, Dorken B, Hartmann G. Antisense therapy in oncology: new hope for an old idea [J] . Lancet, 2001, 358:489-497.
-
3Flaherty KT, Stevenson JP, O'Dwyer PJ. Antisense therapeutics: lessons from early clinical trials [J]. Curr Opin Oncol, 2001, 13:499-505.
-
4Qin GZ, Taylor M, Ning YY. In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha [J]. Antisense Nucl Aced Drug Dev, 2000, 10:11-16.
-
5Agrawal S, Kandimalla ER. Antisense therapeutics: is it as simple as complementary base recongnition [J]? Mol Med Today, 2000, 6:72-81.
-
6Eckstein F. Phosphorothioate oligonucleotides: what is their origin and what is unique about them [J]. Antisense Nucleic Acids Drug Dev, 2000, 10:117-221.
-
7Akhtar S, Hughes M, Khan A. The delivery of antisense therapeutics [J]. Advanced Drug Delivery Reviews, 2000, 33:3-21.
-
8Henry S, Stecker K, Brookds D. Chemically modified oligonucleotides exhibit decreased immune stimulation in mice [J]. J Pharm exper thera, 2000, 292:468-479.
-
9Lambert G, Fattal E, Couvreur P. Nanoparticulate systems for the delivery of antisense oligonucleotides [J]. Adv Drug Deliv Rev, 2001, 7:99-112.
-
10Adah SA, Bayly SF, Cramer H. Chemistry and biochemistry of 2',5'-oligoadenylate-based antisense strategy [J]. Curr Med Chem, 2001, 8:1189-1212.
-
1杜为红,刘京生,王保怀,李芝芬.寡聚核苷酸研究进展[J].保定师专学报,1999,12(4):16-19.
-
2唐宗湘,李葆明,包永德.反义寡聚核苷酸:生理学研究中的新工具[J].生命科学,1999,11(4):180-183. 被引量:4
-
3林静.反义核酸技术及其应用[J].黄石理工学院学报,2010,26(2):46-48. 被引量:3
-
4王玮,朱焕章,薛京伦.RNA干涉在基因治疗中的应用[J].生物化学与生物物理进展,2004,31(7):590-595. 被引量:6
-
5黄秋婵,韦友欢,张卫国.肽核酸在疾病诊疗和分子生物学研究中的应用[J].井冈山医专学报,2008,15(5):10-11. 被引量:1
-
6刘宏伟,周毅,彭淑玲,王香兰.反义寡聚核苷酸对兔角膜基质细胞的通透性[J].眼科,2001,10(4):250-251. 被引量:4
-
7FU Yi-bing WEN Ze-qing ZHAO Xing-bo YAN Lei ZHANG Chun-hua WANG Fei.Inhibitory effect of 2'-o-methoxyethyl-modified antisense oligonucleotides targeting vascular endothelial growth factor A on SKOV3 human ovarian cancer cells[J].Chinese Medical Journal,2011(10):1573-1575.
-
8鲍时翔,凌华,黄惠琴.肽核酸及其在生物学中的应用[J].中国生化药物杂志,2002,23(5):263-265.
-
9REN Ming-hua YU Jing-song SONG Er-lin ZHANG Cheng MA Li JIAO Zhi-xing ZHAO Wei-ming SHAN Yu-juan NI Shao-bin.Antitumor effects of mutant endostatin are enhanced by Bcl-2 antisense oligonucleotides in UM-UC-3 bladder cancer cell line[J].Chinese Medical Journal,2013(15):2834-2839. 被引量:5
-
10王宝林,陈一平.肽核酸及其应用[J].国外医学(微生物学分册),1999,22(5):1-4.