摘要
目的 探讨视觉诱发电位(VEP)对多发性硬化(MS)的诊断价值。方法 将148例MS患者分为临床确诊型(80例)、临床拟诊型(42例)和临床可能型(26例)三组,用模式翻转视觉诱发电位(PRVEP)进行检查。结果 各临床类型MS的P_(100)潜伏期均较对照组显著延长(P<0.01)。各临床类型的VEP异常率分别为80.0％、52.4％和42.3％。有视神经炎病史和视神经萎缩的患者,其VEP异常率显著高于无视神经受累者(P<0.01)。随着病程的延长,VEP异常率有升高的趋势,但未见二者间有显著相关性。VEP异常以P_(100)潜伏期延长和两眼间P_(100)潜伏期不对称性异常多见,分别占44.3％和45.6％。结论 VEP作为一种电生理检查可客观地反映MS患者视觉通路病变所致的电生理变化,为早期发现临床下病灶提供依据,对MS的早期诊断具有重要意义。
Objective To evaluate the diagnostic value of visual evoked potential (VEP) in multiple sclerosis (MS). Method Pattern reversal visual evoked potentials (PRVEP) were tested in 148 patients with confirmed ( 80 eases) , suspected (42 cases) ,and possible (26 cases) MS. Results The latency of P100 in all clinical types of MS was significantly prolonged in comparison with that of control group (P < 0. 001). The abnormal rates of VEP were 80. 0% ,52. 4% and 42. 3% in confirmed, suspected, and possible MS, respectively. The abnormal rate of VEP was significantly higher in MS patients with history of optic neuritis and optic atrophy than that of MS patients without evidence of optic never damage( P < 0. 001 - 0. 01 ) . Abnormal rate of VEP showed a rising tendency with a prolonged period of course, but no significant positive correlation was found between them. Prolongation of P100 latency and the interocular difference of P100 latency had the highest abnormal rates (44.3% and 45.6% respectively) among all abnormal VEPs. Conclusions VEP reflects objectively the electrophysical changes of visual pathway in MS patients and it can provide some evidence for subclinical lesion. Thus,it is a helpful method for the early diagnosis of MS.
出处
《眼科研究》
CSCD
北大核心
2003年第4期422-424,共3页
Chinese Ophthalmic Research
基金
河南省自然科学基金资助(0211044300)
