摘要
目的 :探讨血管内皮生长因子 (vascularen dothelialgrowthfactor ,VEGF)在宫颈癌诊断、治疗以及转移中的临床意义。方法 :酶联免疫吸附分析法(enzyme linkedimmunosorbentassay ,ELISA)测定 2 0例宫颈上皮内瘤样变患者和 60例宫颈癌患者组织中的VEGF含量。结果 :VEGF含量在宫颈上皮内瘤样变、宫颈癌组织中分别为 5 5 6pg/mg、410 2pg/mg ,差异有统计学意义 ,P <0 0 1。肿 瘤≥ 4cm者为 960 0 pg/mg ,淋巴结转移者为 780 5 pg/mg ,而肿瘤 <4cm者 ,淋巴结未转移者分别为 180 5 pg/mg、2 3 0 0pg/mg。差异有统计学意义 ,P <0 0 5。而在临床分期、病理分型、病理分级间差异无统计学意义。结论 :组织VEGF含量检测对宫颈癌的诊断有一定的临床价值 ,其含量变化可监测宫颈癌的转移。
OBJECTIVE:To study the clinical significance of vascular endothelial growth factor (VEGF) on diagnosis, treatment and metastasis in cervical cancer.METHODS:VEGF protein level in 60 cervical cancer tissues and in 20 cervical erosion tissues were measured by enzyme linked immunosorbent assay (ELISA).RESULTS:The median concentrations of VEGF in cervical cancer tissues (410 2 pg/mg) were higher than those in cervical erosion tissues (55 6 pg/mg), P <0 01. Higher levels were also found in tumors larger than 4 cm and pelvic lymph node metastasis, P <0 05, whereas there was no significant difference with the stage,histological type, histological grade, P >0 05.CONCLUSIONS:Tissue VEGF protein level may be a useful marker for cervical cancer diagnosis and may be used as a predictor of lymph node metastasis.
出处
《肿瘤防治杂志》
2004年第2期139-141,共3页
China Journal of Cancer Prevention and Treatment
关键词
内皮生长因子
宫颈肿瘤
肿瘤标记
生物学
vascular endothelial growth factor (VEGF)
cervical neoplasm
tumor markers,biological
