摘要
目的 :探讨胃癌患者血清性激素水平及癌组织中c erbB 2基因表达的临床意义。方法 :采用放射免疫法 ,测定 67例胃癌患者血清黄体生成素 (LH ) ,卵泡刺激素 (FSH) ,催乳素 (PRL) ,睾酮 (T )及雌二醇 (E )水平 ,同时检测癌组织中c erbB 2基因表达。结果 :胃癌患者LH、FSH、PRL水平均高于对照组 ,P >0 0 5 ,T、E2 水平低于对照组。其中 ,男性胃癌患者血清T水平显著低于对照组 ,P <0 0 5 ,与胃癌浸润深度 (P <0 0 5 )、肿瘤大小 (P <0 0 5 )、淋巴结转移 (P <0 0 5 )密切相关 ;胃癌组织中 ,c erbB 2基因表达阳性率为 3 7 3 1% (2 5 /67) ,与胃癌浸润深度(P <0 0 5 )、淋巴结转移 (P <0 0 5 )密切相关 ,与肿瘤大小无关。结论 :男性血清T水平及c erbB 2基因与胃癌生长、浸润、转移有密切关系 ,可作为判断预后的独立指标。
OBJECTIVE:To study the clinical significance of sexual hormones level and c erbB 2 oncogene in gastric carcinoma.METHODS:Serum levels of LH,FSH,PRL,T and E 2 were determined by RIA and c erbB 2 oncogene expression by immunohistochemical staining in 67 patients with gastric carcinoma.RESULTS:The serum levels of LH,FSH and PRL were slightly higher in gastric cancer than those in the normal control, P > 0 05;serum levels of T and E 2 were lower compared with those in the normal control.Serum T levels in male patients were significantly lower than those in the nomal control, P < 0 05;serum levels of T in male patients had a positive correlation with the depth of invasion ( P < 0 05),tumor size ( P < 0 05) and lymph node metastasis ( P < 0 05).Twenty five cancer samples among sixty seven (37 31%) were positive for c erbB 2, and c erbB 2 had a positive correlation with the depth of invasion ( P < 0 05) and lymph node metastasis ( P < 0 05),but its relation to the tumore size was not significant ( P > 0 05).CONCLUSIONS:Serum levels of T and c erbB 2 oncogene are positively correlated with the growth,invasion,metastasis of gastric cancer and could be used as the indicators to evaluate prognosis of gastric carcinoma.
出处
《肿瘤防治杂志》
2004年第2期134-136,共3页
China Journal of Cancer Prevention and Treatment
