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影响胃癌预后的多因素分析 被引量:4

The factors influencing survival of patients with gastric carcinomamultivariant statistical analysis by using cox regression model
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摘要 目的 综合分析和评价胃癌组织中血管内皮生长因子 (VEGF)的表达、微血管密度(MVD)、临床病理因素及术后辅助化疗对胃癌手术预后的影响。方法 对手术切除 112例胃癌组织VEGF的表达、MVD及临床病理因素进行单因素和多因素COX模型分析。结果 单因素分析表明 ,浆膜侵犯、淋巴结转移、pTNM分期、微血管密度与胃癌的预后显著相关 (P <0 0 1) ,而肿瘤大小、生长方式、病理分化程度、血管内皮生长因子、术后化疗等与预后无关 (P >0 0 5 )。经多因素分析表明 ,MVD、pTNM分期及淋巴结转移均是胃癌独立的预后因素 (P <0 0 1或P <0 0 5 )。并且微血管密度高或淋巴结转移病人术后辅助化疗可改善预后 (P <0 0 5或P <0 0 1)。结论 病理分期、淋巴结转移及微血管密度均是判定胃癌预后的有效指标 ,并且可指导术后辅助化疗。
出处 《江苏医药》 CAS CSCD 北大核心 2004年第1期24-26,共3页 Jiangsu Medical Journal
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