摘要
应用气相色谱法测定利多卡因在静脉复合麻醉中的血药浓度,寻找血中较安全有效的浓度,33例均以0.5%利多卡因和0.1%司可林静点维持。于麻醉后30、60、90,120min 和清醒时分别取动脉血作气相色谱分析,测定各阶段利多卡因血药浓度,测出利多卡因静脉复合麻醉的有效量及安全范围为2.1—5μg/ml。本文还研究利多卡因滴数与血药浓度关系。经直线相关分析,60min 前呈正相关关系,90min 后不呈直线相关,麻醉中要维持2.1—5μg/ml 的血药浓度,60min 前需46±10滴/min 90min 后为27.8±5滴/min。说明利多卡因易在体内蓄积,90min 后更显著。故手术结束前50min 应停药方可在手术结束时清醒。
The purpose of this paper was to find a safe and effective concentration of lido- caine in intravenous combining anesthesia.33 cases had been maintained with the intravenous instillation of 0.5% lidocaine and 0.1% scotine the lidocaine concentrations at the period of after introduction,30＇,60＇,90＇,120＇and recovery were measured respectively.The safty and effective range of this drug would be 2.1—5μg/ml. Also,in this paper,the relationship between the rate of instilation and the concentration of Lidocaine was studied.There was a positive correlation between the drope per minute amd the concentration during the period of the first 60 minutes. After 90 minutes from the beginning,there was no linear correlation.If we want to maintain the safty and effective blood concentration(2.1—5μg/ml), the necessary rate of instillation is 46±10 drops/minute during the first 60 minutes and 27.8±5 drops/minute after 90 minutes.This result shows that lidocaine is easy to accumulate obviously in the body.If we want the patient to recover at the time of the operation just performed,we must stop this drug 50 miuutes before the operation is finished.
出处
《昆明医学院学报》
1989年第3期12-15,共4页
Journal of Kunming Medical College
关键词
静脉复合麻醉
气相色谱
利多卡因
Lidocaine
Gas chromatography
Combining anesthesia
