摘要
给于26例临产前产妇口服丙基硫氧嘧啶(PTU)200mg,于胎儿娩出时,立即同时取母静脉血及胎儿脐带静脉血,用高效液相色谱仪测定其PTU浓度。发现母血的PTU浓度(2.878±2.074nmol/L)高于脐血(2.297±1.798nmol/L),P<0.0025。母血与脐血的血药浓度比率为0.91～3.87,平均1.25。提示妊娠期甲亢患者服用PTU时,仍需谨慎,以避免胎儿甲状腺肿和甲减发生。
Twenty-six healthy pregnant women were given 200 mg of propylthiouracil(PTU) prior to delivery, then maternal and cord venous blood of the fetus were collected simultaneously just after delivery for measurement of PTU concentrations by reverse phased high performance liquid chromatography.
The results showed that the plasma PTU in the material and cord blood were 2.878±2.074 nmol / L and 2.297 ±1.798 nmol / L (x±s) respectively. The ratio of PTU in maternal blood to cord blood ranged from 0.91 to 3.87 with a mean of 1.25. It is suggested that a large proportion of PTU can cross the placenta. Therefore, administration of PTU to pregnant women with hyperthyroidism should be guarded lest goiter and hypothyroidism of the fetus should ensue.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1992年第4期203-204,55,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
妊娠
甲亢
丙基
硫氧嘧啶
胎盘
Hyperthyrcidism Pregnancy Propylthiouracil Placental barrier
