摘要
用大鼠垂体细胞灌流技术和ACTH直接法放射免疫测定研究了正常人、Cushing病患者和其他下丘脑-垂体-肾上腺轴疾病患者血浆中的促肾上腺皮质素释放素样生物活性,结合Cushing病患者对神经递质类药物的反应所作观察提出如下假设:绝大多数Cushing病原发于垂体,在发病过程中,高皮质醇血症损害海马,削弱其对下丘脑-垂体-肾上腺轴的抑制作用是一个重要环节。
The plasma corticotrophin-releasing hormone-like bioactivity was measured in normal individuals, patients with Cushing's disease and other diseases of hypothalamic-pituitary-adrenal axis with the techniques of rat pituitary cell peri-tusion and AGTH radioimmunoassay. Combined with the response of the patients to neurotransmitter agonist and antagonist, it was hypothesized that most patients with Cushing's disease have a primary pituitary lesion and that hyper-tisolemia damaging hippocampus and weakening its inhibition on hypothalamic-pituitary-adrenal axis may have an important role in the pathogenesis.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1992年第2期84-87,共4页
Chinese Journal of Endocrinology and Metabolism
