摘要
目的 :探讨以消化不良为主要表现的脾胃湿热证患者血清胃泌素 (GAS)、胃动素 (MTL)、肿瘤坏死因子 α1(TNF α1)、白细胞介素 10 (IL 10 )水平 ,并观察清热化湿方药对其影响与临床疗效。方法 :消化不良为主要表现的脾胃湿热证患者 6 0例 ,随机分清热化湿方药组及多潘立酮组 ,两周后采用酶联免疫吸附法 (ELISA)、放免法 (RIA)分别测定治疗前后血清GAS、MTL及TNF α1、IL 10水平并与 2 0例健康志愿者对照。结果 :脾胃湿热证患者血清GAS ,MTL水平高于正常组 ;中药组治疗后与治疗前相比明显下降 ;多潘立酮组治疗后与治疗前相比明显下降 ,中药组下降水平比多潘立酮组明显 ;脾胃湿热证患者TNF α1高于正常组 ,IL 10低于正常组 ;治疗后中药组TNF α1与治疗前相比明显降低 ,IL 10明显升高但未自调节至正常水平 ;多潘立酮组TNF α1、IL 10虽有变化 ,但与治疗前相比无统计学意义。两组治疗前后症状积分比较均有显著差异 ,中药组疗效优于多潘立酮组。结论 :以消化不良为主要表现的脾胃湿热证患者血清胃动素、胃泌素、肿瘤坏死因子 α1、白介素 10的水平有明显变化 ,清热化湿方药对其有明显调节作用 ;清热化湿方药的临床疗效优于多潘立酮组。
Objective:To investigate the levels of serum gastrin,motilin,TNF-α1,IL-10 in dyspepsia patients of spleen-stomach damp-heat type and to observe the clinical effect of Qing Re Hua Shi decoction.Methods:Sixty cases of spleen-stomach damp-heat type were randomly allocated to control group(n=30),which was treated by domperidone(10mg three times a day)and treatment group(n=30)which was treated by taking orally Qing Re Hua Shi decoction whith a dose of 125ml twice a day.The concentrationt of serum gastrin,motilin,TNF-α1,IL-10 were determined by ELISA and RIA and clinical effect was evaluated in both groups.Compared with a group of twenty common people.Results:Before treatment compared with those of in the common group,the levels of serum gastrin and motilin in the treatment group and control group were significantly increased.After treatment the levels of serum gastrin and motilin in treatment group were markedly decreased.Those of in control group were obviously decreased but not reduced to the normal level.Before treatment compared with those of in common group,the levels of TNF-α1 in treatment group and control group were significantly increased,but the levels of serum IL-10 in both groups were obviously decreased.After treatment the levels of serum TNF-α1 in treatment group were markedly decreased,and the levels of serum IL-10 were distinctly increased but both levels of serum IL-10 and TNF-α1 were not regulated to the normal,and no obviously changes were observed in control group.There were significantly differences between integration of symptoms of before and after treatment in treatment group and control groups,and total effective tate in treatment group was obviously higher compared with those in control group.Conclusion:The levels of serum Gastrin,motilin,TNF-α1 and IL-10 are significantly changed in dyspepsia the patients with dyspepsia spleen-stomach damp-heat syndrome,which can be obviously regulated by Qing Re Hua Shi decoction and the clinical effectiveness of Qing Re Hua Shi decoction is superior to domperidone.
出处
《中国中医基础医学杂志》
CAS
CSCD
2004年第1期63-66,共4页
JOURNAL OF BASIC CHINESE MEDICINE
