摘要
目的:探讨三维适形放射治疗(3-dimensionalconformalradiationtherapy,3DCRT)技术治疗胰腺癌的疗效及生活质量,分析影响预后的因素。方法:31例胰腺癌患者采用3DCRT技术治疗,观察肿瘤局部控制率及1,2年生存率,采用生活质量评分量表进行日常生活活动、疼痛、食欲、睡眠等13项内容综合评估,并用Cox回归比例风险模型分析预后因素。结果:3,12个月时肿瘤局部控制率分别为58.1%,32.3%,1,2年生存率分别是38.2%,7.6%,中位生存期8.3个月。多因素分析结果显示临床分期、生活质量评分对患者生存率的影响具有统计学意义(P<0.05)。结论:3DCRT治疗胰腺癌,能明显改善患者的生活质量及提高生存率,临床分期和生活质量评分对胰腺癌患者的预后有重要影响。
AIM:To investigate the effects of 3-dimensional conformal radiation therapy(3 DCRT) on the pancreatic cancer and the quality of life(QOL) of patients,and anal yze the factors that influence the prognosis of pancreatic cancer. METHODS:Total ly 31 patients with pancreatic cancer were treated with 3DCRT only.The local con trol rates of the cancer and the overall 1-year and 2-year survival rates were noted,thirteen items,including daily life and activity,pain,appetite,sleep,etc. were synthetically assessed by using quality of life scale,and the factors that might influence the prognosis were analyzed with the Cox proportional hazard mod el in multivariate analysis. RESULTS:The local control rates were 58.1% and 32.3% at 3 and 12 months re spectively.The overall 1-year and 2-year accumulative survival rates were 38.2 % and 7.6% respectively,with the median survival time of 8.3 months.The mult iple factor analysis showed that clinical staging and scores of quality of life had statistical significance for the survival rate of the patients(P< 0.05).CONCLUSION:In the treatment of pancreatic cancer with 3DCRT,the QOL and the su rvival rate of the patients can obviously be improved.Clinical staging and QOL a re the two major factors for prognosis.
出处
《中国临床康复》
CSCD
2004年第11期2010-2011,共2页
Chinese Journal of Clinical Rehabilitation
