摘要
前瞻性双盲法临床研究,可评价的恶性肿瘤病人28例,口服齐墩果酸40mg,每日3次,1个月后测定吞噬细胞百分比,由54.1％提高至67.42％。吞噬指数由0.69提高至0.81。迟发超敏反应1:1000浓度转阳性率52.6％(10/19)。E-玫瑰花结试验在本组试验前后无显著变化。同期服用安慰剂的9例对照病人则无变化。治疗后齐墩果酸对骨髓、肝、肾功能均无影响,故可做为比较理想的生物反应调节剂应用于临床,以促进病人的免疫功能。
In a double-blind clinical study, 19 cases with malignant disease were randomized to receive ligustrin(oleanolic acid) 40mg three times a day for one month, while 9 cases were randomized to receive placebo as control. After treat- ment,the percentage of macrophage increased from 54.1% to 67.4% and the phagocytic index increased from 0.69 to 0.81 in treated group. There was no change in these immunologic parameters in the control group. Delayed hypersensiti- vity was observed by 1:1000 OT skin test and was found increased markedly in the treated group. But no change was found with E-rosette test in the treated group.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1992年第6期412-414,共3页
Chinese Journal of Clinical Oncology
