摘要
本文用单克隆抗体Hb3检测了正常献血员(119例)、消化道良性疾病(78例)及胃癌(51例)、结直肠癌(134例)病人血清中的相应抗原CA-Hb3。结果显示,在正常献血员和消化道良性疾病,CA-Hb3的阳性率分别为2.5％和10.3％;而在胃癌和结直肠癌则分别达到47.1％和60.4％。跟踪观察45例结直肠癌病人手术前后CA-Hb3的变化,发现如果在术前血清中CA-Hb3抗原升高,通过肿瘤根治切除后,70.6％病人的抗原水平会在手术后下降;而在非根治切除病例中,大部分为不变和上升(70％)。作者认为CA-Hb3的检测可能有助于消化道肿瘤的诊断和手术治疗效果的判断。
A new tumor-associated antigen CA-Hb3 was measured by McAb Hb3 in individuals of 119 normal blood donors,78 benign gastrointestinal diseaes,51 gastric cancers and 134 colorectal cancers using technics of reversed passive hemoagglutination test.Positive results were noted in normal blood donors and patients with benign gastrointestinal diseases at rates of 2.5% and 10.3% respectively.In contrast,the positive rates in gastric cancers and colorectal cancers was 47.1% and 60.4% respectively.Tracing the pre- and postoperative changes of CA-Hb_3 in patients with cancer,it was demonstrated that the level of CA-Hb3 either dropped in a majority of the patients (70.6%) who underwent radical resection,or remained unchanged when the tumor was partially resecteed.It is suggested that successive measurement of this antigen may be useful in the diagnosis of gastrointestinal cancers and in evaluating the effectiveness of treatment.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1992年第2期120-123,共4页
Chinese Journal of Clinical Oncology
基金
国家科委七.五重点攻关项目
国家自然科学基金资助
关键词
单克隆抗体
胃肿瘤
肠肿瘤
诊断
McAb Hb3
Serodiagnosis
Gastrointestinal cancer
