摘要
气血冲剂治疗冠心病心绞痛气虚血瘀型患者55例,结果表明:气血冲剂有缓解心绞痛、改善心电图缺血性改变的作用;并可提高患者运动耐量和血浆6-Keto-PGF_(1α)水平,降低血浆TXB_2水平以及TXB_2/6-Keto-PGF_(1α)的比值。提示其治疗作用与提高左心功能及调节TXB_2/6-Keto-PGF_(1α)平衡有关。
55 cases of Qi-deficiency and Blood-Stasis syndrome of coronary heart disease (CHD) and angina pectoris (AP) were divided randomly into two groups. Qi Xue granule (QXG) was administered to30 cases of treated group, while compound Salvia tablet (CST) was administered to 25 cases ofcontrol group. Besides, both group were also given one placebo tablet or granule so as to eliminatethe patient's psycological effects. Results: (1) Effects on clinical symptoms: Total effective rate forAP: 90% in QXG group, marked effective rate and effective rate for ischemic ECG changes were 30%and 46.6% respectively. All of these were better than that of CST group significantly (P<0.05).Besides, QXG group could alleviate symptoms including asthenia. (2) Effects on submaximal. paddlework load test: QXG group could prolong the capacity of exercise (from 336.2 ± 34.7 to 437.5 ± 43.8seconds, P<0.05), magnify the work load (from 73 ± 17.18 to 94 ± 8.5W, P<0.05) and elevaete the STsegment (from 0.218 ± 0.03 to 0.176 ± 0.mV) significantly in camparison with CST group, which had little change only. (3) Effects on plasma TXB_2, 6-keto-PGF_(1α) (6Kp) level and ration of TXB_2/6Kpin 10 normal subjects were 165 ± 12.1 pg/ml, 142.6 ± 17.4 pg/ml and 1.16 ± 0.19 pg/ml respectively,while in 36 cases AP were 390.6 ± 14.3. 106.0 ± 7.9 and 3.67 ± 0.85 pg/ml respectively. Aftertreatment, the TXB_2 of QXG group reduced from 390.0 ± 22.4 to 139.2 ± 13.9 pg/ml (P<0.01) andthe ratio of TXB_2/6Kp decreased from 3.85 ± 0.26 to 0.9 ± 0.12 (P<0.01) and 6Kp elevated from104 ± 11.4 to 177.0 ± 14.0 pg/ml (P<0.01); The TXB_2 of CST group lowered from 391.0 ± 18.6 to194.1 ± 13.6 pg/ml (P<0.01) and the ratio of TXB_2/6Kp from 4.0 ± 0.38 to 1.69 ± 0.17 (P<0.01), but6Kp changed unsignificantly. In summary, Qi Xue Granule could alleviate angina pectoris andimprove symptoms, myocardial ischemia and functions of left ventricle, and also adjuste TXA_2-PGI_2balance effectively, which were taken as the machanism contributing to alleviate AP an mprove symptoms. It suggests that Qi Xue Granule is an effective antiangina medicine.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1992年第11期663-665,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
冠心病
血栓素
心气虚
coronary heart disease
angina pectoris
Blood-Stasis
Qi-Deficiency
Qi Xue granule
Salvia tablet
ECG
thromboxane
