摘要
将60～80岁具有肾虚衰老症状的健康男性80例,随机分为五子衍宗液组及糖水安慰剂组,采用单盲法,服药5周。结果表明:五子衍宗液可使老年肾虚衰老症状的总积分值下降(P<0.01),红细胞中超氧化物歧化酶(SOD)活力升高(P<0.01),血浆过氧化脂质(LPO)含量下降;血浆睾酮(T)含量上升(P<0.01),雌二醇(E_2)与T比值下降(P<0.01)。而糖水安慰剂组治疗前后均无明显变化。提示减少自由基中毒损伤,增强抗氧化酶活力及调节体内性激素水平,可能是五子衍宗液治疗老年肾虚、延缓衰老的主要作用机制之一。
Eighty men ranging from 60 to 80 years old were selected, in whom no disease was found through a thorough check-up except for some senility manifestation diagnosed as deficiency of the Kidney. They were randomly divided into two groups, Wuzi Yanzong Solution (WYS) being administered in 50 cases and placebo in 30. After 5 weeks' treatment, symptoms such as hypomnsis, tinnitus, and aching of the back and legs, dribbling after urinary voiding, and nocturia were remarkably improved in the WYS group, but they remained as before in the placebo group. Before the treatment, plasma lipid peroxide (LPO), erythrocyte superoxide dismutase (SOD), blood glutathione peroxidase (GSH-Px), serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH), plasma testosterone (T) and estradiol (E_2) levels were determined. In comparison with the results obtained in 33 young men in their twenties. LPO, FSH, LH level and E_2/T ratio in the aged were greatly elevated, and SOD, GSH-Px and T markedly lowered.After the treatment, there was remarkable reduction of LPO and E_2/T, and increase of SOD and T in the WYS group, but no significant change in the placebo group. The above results not only indicate the beneficial effect of WYS in retarding the aging process, but also suggest the possible mechanism of reducing the peroxidation of fatty acids by enhancing the antioxidant enzymes to inhibit free radical activity.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1992年第1期23-25,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
五子衍宗液
自由基
肾虚
抗衰老
Wuzi Yanzong Solution
aging process
free radical
endocrine
