摘要
目的 评价超声造影剂Levovist对彩色多普勒血流显像 (CDFI)检测卵巢肿瘤血管的增强效应 ,探讨其在鉴别诊断卵巢良、恶性肿瘤中的应用价值。方法 应用CDFI检查 19例卵巢肿瘤 (7例良性肿瘤 ,12例恶性肿瘤 ) ,比较注射Levovist前后肿瘤内血管显像情况 ,包括血管数目、血管扭曲度以及多普勒信号增强情况 ,并建立受试者工作特性曲线 (曲线 )ROC。结果 与卵巢良性肿瘤相比 ,卵巢恶性肿瘤造影后彩色多普勒血流信号明显增强 ,并显示特征性的血管形态 ,血管数目明显增多 ,血管扭曲度增加 ,且多普勒信号增强出现早、到达高峰快、持续时间长。ROC曲线显示 :造影后血管多普勒信号增强开始时间≤ 5 0s ,到达高峰时间≤ 10 0s ,持续时间≥ 40 0s时 ,诊断恶性肿瘤的敏感性、特异性最高。结论 超声造影剂Levovist的应用有助CDFI更准确地评价肿瘤的血管 ,对卵巢良、恶性肿瘤的诊断、鉴别诊断与指导治疗均有重要的应用价值。
Objective To assess the efficacy of ultrasound contrast agent Levovist in evaluating vascularization of ovarian tumors.Methods Nineteen ovarian lesions (seven benign ovarian tumors,twelve malignant ovarian tumors) were submitted to color Doppler flow imaging (CDFI) before and after i.v.Levovist for examining their vascularization,including the number of blood vessel,vessel torsion and Doppler signal enhancement. And then receiver operator characteristic(ROC) curves were established.Results Compared to benign tumors',after contrast color Doppler signals in malignant tumors enhanced obviously and character characteristic vessel morphologies were observed.Vessel numbers and tortuosity increased obviously.Doppler signal enhancement appeared earlier,arrival to peak enhancement was quicker,and duration longer.ROC showed time to commencement for the enhancement ≤50 s,time to peak ≤100 s and enhancement duration ≥400 s,at which the sensitivity and specificity were the highest.Conclusions Levovist,as a contrast agent, increases the intensity of color Doppler signals obviously,and allows a more complete display of the vascular patterns of ovarian tumor.It improves markedly the role of CDFI in the diagnosis and differentiation of ovarian tumors.
出处
《中华超声影像学杂志》
CSCD
2003年第9期534-537,共4页
Chinese Journal of Ultrasonography
