摘要
在重度失血性休克大鼠上(MAP=3.33～3.87kPa)观察到,静脉注射胰高血糖素(20μg/kg)不仅使动脉血压回升,心率加快;而且还明显增加残余循环血量。用注射高渗葡萄糖的方法模拟胰高血糖素所致的高血糖浓度,提示胰高血糖素的升压作用与其升糖作用没有明显的关系。实验结果表明,胰高血糖素对急性失血性休克大鼠有良好的抗休克作用,其升压效应可能是通过增加心输出量和循环血量实现的。
Glucagon (20μg / kg i.v.) induced not only increase in mean arterial blood pressure (from 3.6 to 11.6 kPa) and heart rate (from 216 to 353 beats/min), but also significant increase in volume of residual circulating blood (from 1.02 to 1.84 ml/100g) in the rats with severe hemorrhagic shock. Although glucagon also significantly increased the blood glucose concentration (from 123 to 161 mg%), injection of glucose (50%, 0.2ml / 100g iv.) did not show obvious effect on the arterial blood pressure at high blood glucose concentration (166 mg%). The results suggest that the anti-shock effect of glucagon may be due to increase in cardiac output and volume of circulating blood.
出处
《中国应用生理学杂志》
CAS
CSCD
1992年第3期228-231,共4页
Chinese Journal of Applied Physiology
关键词
失血性
休克
胰高血糖素
动脉血压
hemorrhagic shock
glucagon
arterial blood pressure
blood volume
