摘要
本文报道7名健康受试者分别口服1g单剂量扑热息痛滴剂(A)、酏剂(B)和片剂(C)后的生物利用度和药代动力学比较。血药浓度用紫外分光光度法测定。结果表明:A和B比C吸收迅速、达峰早,Cp和AUC较C犬(P均<0.05)。与C相比,A和B能维持在有效治疗血浓的时间更长。A和B更适合于儿科应用。
Paracetamol bioavailability and pharmacokinetics were compared following oral administration of lgsingle dose of paracetamol oral drops A, elixir B and tablet C to 7 healthy volunteers. The drug plasmaconcentrations were measured using a UV method. The Ka Cp AUC obtained following dosing with A and Bwere significantly higher than those for C. The T_p was reached in a shorter time after dosing with A and Bcompared to C. The maintainable-time of effective concentration of A and B was longer than C. A and B aremore suitable for pediatric than C.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1992年第8期345-346,共2页
Chinese Journal of Hospital Pharmacy
关键词
扑热息痛
药代动力学
口服滴剂
Paracetamol
Bioavailability
Pharmacokinetics
Oral drops
Elixir
