摘要
本实验采用紫外分光光度法测定了五种头孢菌素类抗生素(即头孢唑啉钠、头孢哌酮钠、头孢噻甲羧肟、头孢唑肟钠、头孢三嗪)的含量及其与常用输液配伍的稳定性。结果表明:头孢唑啉钠、头孢哌酮钠、头孢唑肟钠、头孢噻甲羧肟与蒸馏水、生理盐水溶液、10%葡萄糖溶液在室温下(25～30℃) 配伍稳定,24h内含量变化不大。头孢三嗪与10%葡萄糖溶液配伍后6h含量低于原含量90%,故不宜与葡萄糖溶液配伍使用。本实验还提示此类药物在弱酸条件下较为稳定。本实验结果可供临床配伍使用参考。
UV spectrophotometry was used to determine the content of five cephalospo-
rins, i. e. cefazolin, cefoperazone, ceftazidime, ceftizoxime and ceftriaxone, and
to test their concentration chang after combination with routine transfusion solu-
tions. The result showed that cefazolin, cefoperazone, ceftazidime and ceftizoxine
were stable when combined with distilled water,normal saline,or 10% glucose
solution under room temperature (25～30℃), the content of which changed very
little within 24 hours. The combination of ceftriaxone with 10% glucose solution
was unstable,for its content turned to be less than 90% of the original content 6
hours after combination. Our result also suggested that these cephalosporins were
relatively stable under slight acidic conditions, which was informative to clin
ical combinational usage.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1992年第4期168-170,共3页
Chinese Journal of Hospital Pharmacy
关键词
分光光度法
头孢菌素
配伍
输液
UV spectrophotometry
stability of combination
Cephalosporins
transfusion
