摘要
法莫替丁对大鼠应激性、消炎痛性及组胺性胃溃疡均有良好的保护作用,还能促进醋酸所致胃溃疡的愈合。明显抑制大鼠的基础胃酸分泌和组胺、胃泌素及匹洛卡品刺激的胃酸分泌。上述作用呈明显的剂量依赖性,其作用强度约为雷尼替丁的6～8倍。
Famotidine was effective to prevent the development of the acutegastric ulcer induced by stress,indomethacin or histamine.It also promoted thehealing process of chronic gastric ulcer induced by acetic acid and could inhibitthe secretion of basic gastric acid and the secretion stimulated by histamine,gastrin as well as pilocarpine in dose-dependent manner and it was 6～8 timesmore potent than ranitidine.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1992年第12期540-542,553,共4页
Chinese Journal of Pharmaceuticals
关键词
法莫替丁
胃溃疡
溃疡病用药
famotidine
ranitidine
gastric ulcer
gastric acid secretion
prevention
therapy
