依那普利、缬沙坦逆转高血压患者左室肥厚的疗效分析被引量：5

Clinical observvation of which remedy left ventricle hypertrophy of hypertension patients by enalapril, valsartan

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摘要目的　对依那普利、缬沙坦逆转高血压患者左室肥厚的疗效进行对照研究。方法　选取高血压患者80例,经予以依那普利、缬沙坦各40例治疗6个月,分别测定左室舒张末期内径(LVEDD)、室间隔舒张末期厚度(IVST)及左室后,壁舒张末期厚度(LVPWT)后计算左室重量及采用平衡放射免疫分析法测定血清Ⅰ型前胶原羧基端肽(PIP)、Ⅲ型前胶原氨基端肽(PⅢP)水平。结果　左室重量指数与血清PIP、PⅢP水平显著正相关,而予以依那普利、缬沙坦治疗后血清PIP、PⅢP水平较治疗前显著降低。结论　ACEI及ARB可逆转高血压患者的左室肥厚,提高患者的生存质量。 Objective To do comparative study of which remedy left ventricle hypertrophy of hypertension patients by Enalapril, Valsartan.Methods 80 cases hypertension patients were chosen and divided two groups. Two groups were treated separately by enalapril, valsartan. LVEDD,IVST and LVPWT were determined separately before and after 6 months treatment so as to calculate left ventricle weight.Result The serum PⅠP,PⅢP level were determined by BRIA way. The result showed left ventricle weight index and the serum PⅠP,PⅢP level had remarkable positive relationship. the patients were given enalapril, valsartan, the serum PⅠP ,PⅢP level remarkably lowered than before.Conclusion ACEI and ARB can remedy left ventricle hypertrophy of hypertension patient sanf and improve Living quality of patients.

作者郑琼

机构地区广东省江门市第二人民医院

出处《宁夏医学杂志》 CAS 2004年第4期207-209,共3页 Ningxia Medical Journal

关键词高血压左室肥大依那普利 Hypertension Left ventricular hypertrophy Enalapril

分类号 R541.3 [医药卫生—心血管疾病]

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