摘要
合成了3-取代苯基-5-取代-1,2,4-(口恶)二唑类化合物50个,经感染棘球蚴的小鼠初筛,部分化合物对棘球蚴有不同程度的作用,化合物13、28和30对棘球蚴的囊重抑制率分别为70、75.6和71.6%,其中化合物13对棘球蚴的生发层有损害作用。
Fifty 3-substituted phenyl-5-substituted-1,2,4-oxadiazoles havebeen synthesized for screening against Echinococcus granulosus in mice.The cystinhibition rates for 13,28,30 were 70,75.6 and 71.6%,respectively.The germi-nal layer of the hydatid was damaged by 13.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1992年第6期251-254,共4页
Chinese Journal of Pharmaceuticals
关键词
抗棘球蚴药
合成
antihydatic agent
3-(4-substituted aminophenyl)-5-substituted-1
2,4-oxadiazole
3-(4-substituted methylene iminophenyl)-5-substituted-1,2,4-oxadiazole
