摘要
用Western印迹技术检测 2型糖尿病患者腹部皮下脂肪组织内胰岛素受体底物 1与 2 (IRS 1和IRS 2 )的蛋白表达。结果提示 2型糖尿病患者脂肪组织IRS 1蛋白表达减少和IRS 2蛋白表达未变。IRS 2可能是主要的docking蛋白 ,并可能是引起 2型糖尿病高胰岛素血症及胰岛素抵抗的因素之一。
The levels of protein expressions o f insulin receptor substrate-1 and -2 (IRS-1 and IRS-2) in abdominal subcuta neous adipose tissue from type 2 diabetic patients were measured by Western blot technique. The expression of IRS-1 protein was reduced and the expression of I RS-2 protein was unchanged in adipose tissue of type 2 diabetic patients. IRS- 2 may be the main docking protein and one of the factors causing hyperinsulinemi a and insulin resistance in type 2 diabetes mellitus.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2003年第5期392-393,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
胰岛素受体底物
脂肪组织
表达
2型糖尿病
Insulin receptor substrate-1
Insulin receptor substrate-2
Diabetes mellitus, non-insulin-dependent
Insulin resis tance
