摘要
博莱霉素所致肺急性(7d)与亚急性(21d)炎症时,肺内组织胺含量明显升高;而764-3则可使肺组织胺含量下降至接近正常。另外,组织胺对肺成纤维细胞具有时间及剂量依赖性促生长作用,764-3可抑制这一作用。提示组织胺在博莱霉素致肺纤维化中具有一定作用,764-3对这一过程有抑制作用。
The changes of histamine content in inflamed lungs induced by bleomycin, lung fibroblast proliferation enhanced by histamine and the effect of 764-3 on these parameters were investigated. Results showed that: 1) after intratracheal instillation of bleomycin for 7 and 21 days, the lung histamine content increased significantly, and 764-3 inhibited this increase of histamine content: 2)histamine enhanced the prcliferation of lung fibroblasts in a dose-and time-de-pendent manner, and 764-3 inhibited the proliferation of lung fibroblasts in both normal and histamine-enhanced conditions. Results suggested that both inhibitory actions (direct inhibition of fibroblast proliferation and indirect action stemming from a reduction in the histamine content increase) might be involved in the antifibrotic mechanism of 764-3.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1992年第1期72-74,共3页
Acta Academiae Medicinae Sinicae
