摘要
目的探讨介入治疗方法在中晚期乳腺癌病人术前的临床应用。方法23例经临床证实的中晚期(Ⅱ～Ⅳ期)乳腺癌患者术前均行介入治疗。采用Seldinger技术于局麻下经股动脉穿刺,将导管超选择送至乳腺癌的供血动脉内。经导管将盐水稀释过的顺铂40mg～60mg,丝裂霉素6mg～10mg,5-FU750mg～1250mg,阿霉素60mg～100mg,氨甲蝶磷600mg等化疗药二联或三联缓慢注入靶血管内,如有必要可用明胶海绵将其栓塞,术毕,拔除导管,局部加压包扎。结果23例病人经1次至2次治疗后,完全缓解(CR)1例,部分缓解(PR)20例,稳定(S)1例,以及进展(P)1例,总有效率(CR+PR)为91.3%(21/23)。20例又行根治性手术。术后有5例病人继续行该治疗。经介入治疗加手术治疗的病人,其中位生存期延长到31个月。结论介入治疗为中晚期乳腺癌病人提高手术疗效、延长寿命提供了有效的方法。
Objective To investigate the clinical application of preoperative interventional therapy in the patients with intermediate and advanced breast cancer.Methods Twenty-three patients in the study underwent the interventional therapy before the operation.In all patients the interventional therapy was performed by using Seldingers technique,catheterial head was ultraselectly sent into tumor′s feeding artery, chemotherapic protocol was two or three combination of cis platinum(40～60 mg),mitomycin(6～10 mg),5 FU (750～1 250 mg),adriamycin(40～60 mg).If necessary,gelform could be used for the embolization.Partial patients underwent repeated treatment for twice or three times.Results Following the interventional therapy for once or three times,complete relieve(CR)was found in one case,partial relieve(PR) in 20 cases,stabilization(S)in one case,and progression(P)in one case,the total effective rate was 91.3 %,20 of23 cases underwent again the radical operation,of them,5 cases continued for the interventional therapy after the operation.Among the patients received the both of interventional therapy and operation,their mid survival term prolonged to 31 months.Conclusion Preoperative interventional therapy is an effective means for increasing the operative effects and prolonging the survival term of the patients with intermediate or advanced breast cancer.
出处
《实用医学影像杂志》
2004年第1期49-51,共3页
Journal of Practical Medical Imaging
关键词
乳腺癌
介入治疗
生存期
手术
Breast cancer
Interventional therapy
Survival term
Operation
