摘要
用妊娠24日母兔的胎仔,施行宫内手术,制作胎粪性腹膜炎模型,用以研究胎仔期胎粪性腹膜炎的病理演变规律。结果发现:胎粪进入腹腔后,先以纤维素性渗出为主,术后第3日即可形成纤维性粘连,并出现钙化斑;^(45)Ca放射自显影证明,胎粪进入腹腔后,体内^(45)Ca重新分布,在腹腔病变区密集;模型胎仔总体发育落后,肠管细、粘膜层薄更为突出;用X线衍射及红外光谱分析,钙化斑的成分以结晶体羟磷灰石为主。本实验对胎粪性腹膜炎在胎儿期的形成和演变规律的发现有重要的理论意义和指导临床工作的价值,也为我国开展胎儿外科技术打下基础。
Animal. models of meconium peritonitis was made on restated rabbits of 24 days by fetal surgery method to study the pathological changes of meconium peritonitis in fetal period. The results showed that under the influence of meconium introduced to abdominal cavity, fibrinous exudate was the main change, and 3 days later fibrinous adhesiveness and calcification were observed, ^(45)Ca autoradiography showed that the ^(45)Ca in the body was redistributed and concentrated in the lesion. The fetus development was retarded especilly the intestinal, tract and mucosa. The findings of the development and the pattern of meconium peritonitis in fctal perial showed an important theoretical and clinical value and laid the foundation to fetal surgery.
出处
《中国医科大学学报》
CAS
CSCD
1992年第2期113-116,共4页
Journal of China Medical University
基金
国家自然科学基金
关键词
胎粪性
腹膜炎
动物模型
病理学
meconium peritonitis
fetal surgery
animal model
rabbits
pathology
