摘要
目的 观察急性冠脉综合征 (ACS)早期辛伐他汀治疗对血脂和炎症反应标记物的影响及差异 ,探讨他汀类药物在ACS早期治疗中的作用。 方法 ACS住院患者 12 3例 ,入院后测定血浆甘油三酯 (TG)、总胆固醇(TC)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、白细胞介素 6 (IL 6 )和C反应蛋白 (CRP)水平 ,然后随机分为辛伐他汀治疗组和非辛伐他汀治疗组。出院时重复测定上述指标。同期测定 15例慢性稳定性心绞痛 (CAP)患者和 15名健康者作对照比较。 结果 1 ACS患者血浆TC、LDL C、IL 6、CRP显著高于健康者 (P <0 0 1) ,血浆LDL C、IL 6显著高于CAP患者 (P <0 0 1)。 2 出院与入院时比较 ,辛伐他汀组和非辛伐他汀组血浆IL 6、CRP显著降低 (P <0 0 1) ,出院时辛伐他汀组血浆IL 6、CRP也显著低于非辛伐他汀组 (P <0 0 1)。 3 据入院时血浆IL 6、CRP水平 ,把ACS患者分别分为IL 6、CRP高值组和低值组 ,出院与入院时比较 ,高值组和低值组血浆IL 6、CRP均显著降低 (P<0 0 1,P<0 0 1) ,但只有高值组 ,出院时辛伐他汀治疗者血浆IL 6、CRP显著低于非辛伐他汀治疗者 (P <0 0 1,P <0 0 5 )。 结论 ACS患者早期辛伐他汀治疗有明显抗炎症作用。
Objective To observe the effects and differences of simvastain on serum lipids and markers of inflammation at the early stage in the patients with acute coronary syndrome(ACS). Methods Serum triglycerides(TG),total cholesterol(TC),LDL cholesterol(LDL-C),HDL cholesterol(HDL-C),interleukin-6 (IL-6) and C reactive protein(CRP) were measured in 123 hospitalized patients wit h ACS after admission,then the patients were randomly divided into 2 groups to receive simvastatin 2 0mg daily or nonlipid-lowering therapy.At being discharged from hospital all above parametes were a ssayed again.The same paramtes were also assayed in 15 hospitalized patients wi th chronic angina pectories(CAP) and 15 healthy people. Results 1.Compared with healthy people the serum TC,LDL-C,IL-6 and CRP were elevated significantly in ACS patients( P <0.01),whereas the serum LDL-C and IL-6 in ACS patients were markedly higher than in the CAP patients( P <0.01).2. The serum IL-6 and CRP at th e time of discharge were significantly decrease and compared with that at the time of admission or non-simvastatin groups( P <0.01),but also the levels of IL-6 and CRP were much more lower in simvastatin group than non-simvastatin group( P <0.01).3.The patients with ACS,regardless of whether the levels of serum IL-6 and CRP were higher and lower, all their seru m IL-6 and CRP were significatly decrease at the time of discharge in each group( P<0.01,P <0.01),but statin therapy group were much more lower than non-simvastatin group( P<0.01,P <0 .05). Conclusion Shavastatin has anti-inflammatory therapeu tic effects in patients with ACS at the early stage.
出处
《实用心脑肺血管病杂志》
2004年第2期76-80,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
