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P2X嘌呤受体与痛觉调制 被引量：1

P2X Receptor and Nociceptive Modulation
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摘要 嘌呤受体可分为P1和P2受体,在后者的诸亚型中仅P2X受体属配体门控离子通道受体,P2Y受体及其他亚型均为G蛋白耦联受体。P2X受体与伤害性感受器的分布相一致,并参与不同疼痛的调制。现就P2X受体以及其在不同疼痛状态中的作用作一简要综述。
作者 耿桂启 张励才 曾因明
机构地区 徐州医学院
出处 《国外医学（麻醉学与复苏分册）》 2004年第2期68-71,共4页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
关键词 P2X嘌呤受体 痛觉调制 ATP 伤害性感受器
分类号 R614 [医药卫生—麻醉学]
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参考文献23

  • 1Stanfa LC, Kontinen VK, Dickenson AH. Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, earrageenan-infiamed and neurepalhic rats. Br J Pharmacol, 2000,129: 351-359.
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  • 3Holton P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol (Lond) 145:494-504.
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  • 6Barclay J, Patel S, Dom G, et al. Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci,2002,22:8t39-8147.
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  • 8Hamilton SG, Wade A, McMahon SB.The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol, 1999,126:326-332.
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同被引文献11

  • 1陈鸣,吕军,向正华,焦炳华.离子通道受体P2X4的结构及生物学功能[J].生命的化学,2004,24(5):403-405. 被引量：1
  • 2J Pablo Huidobro-Toro,Ramón A Lorca,Claudio Coddou.Trace metals in the brain:allosteric modulators of ligand-gated receptor channels,the case of ATP-gated P2X receptors.Eur Biophys,2008,37:301-314.
  • 3Heike Franke,Ute Krügel,Peter Illes.P2 receptors and neuronal injury.Pflugers Arch-Eur J Physiol,2006,452:622-644.
  • 4Taka-aki Koshimizu,Gozoh Tsujimoto.Functional Role of Spliced Cytoplasmic Tails in P2X2-Receptor-Mediated Cellular Signaling.Pharmacol Sci,2006,101:261-266.
  • 5Daryl L Davies,Andrei A Kochegarov,Sacha T.Kuo et al.Ethanol differentially affects ATP-gated P2X3 and P2X4 receptor subtypes expressed in Xenopus oocytes.J Neuropharmacology,2005,49:243-253.
  • 6Forrest F Weight,Chaoying Li,Robert W Peoples.Alcohol action on membrane ion channels gated by extracellular ATP (P2X receptors).Neurochemistry International,1999,35:143-152.
  • 7Ronstoop,Annmarie surprenant R.alan north.Different Sensitivities to pH of ATP-Induced Currents at Four Cloned P2X Receptors.Neurophysiol,1997,78:1837-1840.
  • 8Luca Antonioli,Matteo Fornai,Rocchina Colucci,et al.Regulation of enteric functions by adenosine:Pathophysiological and pharmacological implications,2008,120(3):233-253.
  • 9山丽梅,赵艳玲,金城,张萍,蔡光明,肖小河.嘌呤P2受体的分子生物学研究进展[J].中国药理学与毒理学杂志,2007,21(4):293-296. 被引量：6
  • 10王文,武胜昔,李云庆.P2X_4受体在大鼠神经系统的分布[J].解剖科学进展,2001,7(4):289-293. 被引量：3

引证文献1

国外医学（麻醉学与复苏分册）
2004年 第2期

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