摘要
本文对24例结核病患者(男女各12人)做了利福平药代动力学的比较研究。口服利福平450mg后于不同时间采取血标本,用高效液相色谱法(HPLC)测定血浆药物浓度,用3P87程序处理,求出相应时间浓度曲线及各组药代动力学参数值。研究结果表明,男性和女性患者之间,其达峰时间(Tpeak)、吸收速率常数(Ka)、表观分布容积(Vd)无显著性差异(P>0.05),达峰浓度(C_(max)),血浆清除半衰期(T_(1/2 Ke)及清除率(CL)有显著性差异(P<0.05)。男性和女性患者组各自数值分别为:8.36μg/ml,1.06h,9.196L/kg·h 和12.06μg/ml,1.808h 及17.54L/kg·h。
Pharmacokinetics of rifampin was studied comparatively in 24 patients with tuberculosis(12 were males and 12 females).Their blood samples were collected at different time after oral administration of450 mg rifampin.The plasma drug concentration wasdetermined by HPLD method,3P87 program wasused for fitting concentration-time curves and calcu-lating kinetic parameters.The results indicate that thepeak time(Tpeak),absorption rate constant(Ka),andvolumes of distribution(Vd)were not significant(P>0.05)between the male and female patients.Thepeak concentrations(C_(max)),half-life of elimination(T_(1/2)Ke),and clearance(CL)were significantly dif-ferent(P<0.05).They were 8.36 g/ml,1.06/hand 9.20L/h for the male patients and 12.06 g/ml,1.808/h and 17.54L/h for the female patientsrespectively.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1992年第4期211-212,共2页
Chinese Pharmaceutical Journal
关键词
利福平
药代动力学
结核病
rifampin
pharmacokinetics
tuberculosis
