摘要
观察40例原发性高血压患者循环血中6—Keto—PCF_(1α)LPO,TXB_2及血脂水平。随机将病人分为粉防己碱组(每次0.1～0.2g。Tid,po,n=22)和硝苯啶组(每次5～20mg,Tid,po,n=18),治疗3个月,发现两药在降压的同时尚使TXB_2、LPO、apoB_(100)水平降低,使6—KetO—PGF(1u)和apoA;水平升高.硝苯啶还有降低血脂作用,而粉防己碱则无此作用。提示粉防己碱与硝苯啶有促进PGI_2合成,抑制TXA_a释放和抗过氧化作用。
The effects of tetrandrine on serum TXB2, 6 - Keto - PGF1α, LPO and lipids in patients(n= 40)with essential hypertension has been studied. The results showed that: (1) The levels of serum 6 - Keto -PGF1α,apoA1 in EHT were lower and the level of serum TXB2,LPO and apoB100 were higher than those in control. (2)Patients with essential hypertension treated with tetrandrine (0.1 ~ 0. 2g,tid,po)for 3 mon revealed that the
levels of TXB2, LPO and apoB100 were decreased, and the levels of apoA1 and 6 - Keto - PGF1α were increased. In conslusion,tetrandrine stimulated the synthesis of PGI2 and inhibited the release of TXA2 and normalized the metabolism of lipids in patients with essential hypertension.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第6期436-439,共4页
Chinese Pharmacological Bulletin
关键词
粉防己碱
高血压
前列腺素
tetrandrine
essential hypertension
apoB_(100)
apoA_1
prostaglandins
h-pidic peroxidation
