摘要
苄普地尔iv能明显提高乌头碱诱发大鼠心律失常用量及豚鼠心脏哇巴因中毒耐量;对BaCI_2、Adr诱发的实验性心律失常有明显对抗作用;对大鼠冠脉结扎复灌注引起的心律失常有保护作用。
Bepridil (10mg · kg-1) iv elevated the threshold dose of ouabain (15ug · min-1 iv) in guinea-pig and aconitine (10μg · kg-1 · min-1 iv) in rat induced ventricular extrasystole, ventricular tachycardia, ventricular fibrillation and cardiac arrest. It shortened the duration of arrhythmia elicitde by Adr (50ug · Kg-1 iv) in conscious rabbits and by BaCl2 (3mg · kg-1 iv) in rats. It is also effective in preventing reperfusion-induced arrhythmias in aneasthetized rats.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第4期285-287,共3页
Chinese Pharmacological Bulletin
关键词
苄普地尔
心律失常
Bepridil
A conitine
Ouabain
Bad_2
CaCl_2
Adrenaline
Reperfusion
Anhythmia
