摘要
本文探讨人参皂甙通过神经内分泌系统间接介导的免疫增强作用。研究结果;将微量人参皂甙经导管直接导入双侧海马(5×10^(-8)kg/侧,连续给药4d后,能明显增强脾脏T淋巴细胞ConA增殖反应,增强IL—2的产生,促进IL—2R的表达;提高SAC菌诱导的脾脏B淋巴细胞增殖反应;增强脾脏NK细胞活性.这提示人参皂甙可能通过海马介导脾脏免疫功能增强效应。
Enhancing effect of gin-senosides (GS) on immune function indirectly via hippocampus (HC was studied in this paper. The main results indicated that after the injection of GS into bilateral HC of rat directly by implantation at the dose of 5×10~8 kg per day for 4 days, splenocyte proliferative response to ConA was enhanced significantly as compared with control group. But after injection of GS into abdominal cavity with the same dose, no significant change of splenocyte proliferation to ConA was found. Be-
sides , our data also indicated that GS, injected into HC, could promote NK cell activity, increase proliferative response of spleen B lymphocytes to SAC bacteria, enhance IL -2 production and IL -2R expression of spleen T lymphocytes. The study showed that GS could promote indirectly the immunce function of spleno-cytes via HC.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第3期214-217,共4页
Chinese Pharmacological Bulletin
关键词
人参皂甙
海马
免疫
淋转
ginsenosides
hippocampus
IL - 2
NK cell
lymphocyte proliferation
