摘要
用人参多糖致敏家兔后,采集血清,用体外细胞毒试验证明;人参多糖致敏血清对人和鼠的肿瘤细胞株有不同程度的杀伤作用。从血清中提取的有细胞毒活性的粗提液经局部和静脉注入荷瘤动物体内.24h后,肉眼可见肿瘤局部和中心有坏死褐色变区域;镜下可见:肿瘤组织出现出血、坏死,细胞核浓缩、破碎、溶解、消失等。通过系统实验结果综合分析,认为人参多糖具有一定的抗肿瘤活性,其机制可能是人参多糖诱生了肿瘤坏死因子。
Rabbits were sensitized by Ginseng polysaccharide then the serum of the rabbits was collected and tested for the cytotoxity activity. The cytotoxic experiment in vitro revealed that the serum has cytotoxity in various degrees against maligant tumor cell lines of human and murine. The partly separated and purified immuned serum was injected into the Ehrlich 180 solid tumors of BALB/C mice. The fascinating hemorrhagic necrosis were find in the solid tumor. The bio-
logical and physical feature of purified immuned serum were also analysed. The results indicate that the Ginseng polysaccharide can induce the endogenous production of TNF. The rabbit TNF was stable at 56℃ 30min. This results provided a reliable theoretic basis for the application of Ginseng polysaccharide in anti - tumor treatment.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第3期218-220,共3页
Chinese Pharmacological Bulletin
关键词
人参多糖
细胞毒因子
ginseng polysaccharide
anti tumor activity
