摘要
1—(α—萘甲基)2—甲基—6,7—二甲氧基—四氢异喹啉;;α—肾上腺素受体;;
The blocking action and selectivity of 1 - (α -naphthylmethyl)-2 - methyl - 6,7 - dimethoxy -1,2,3,4 -tetrahydroisoquinoline (86040) on a - a-drenoceptor have been investigated in isolated tissues. 86040 suppressed the inhibition of clonidine for the electrically stimulated twitch response of rat vas deferens ( - adre - noceptor), with pA2 value of 5. 85. 86040 could competitively inhibit anococcygeus muscle contraction (α1 -a-
drenoceptor ) induced by phenylephrine with pA2 value of 7. 62. 86040 was found that the selectivity radio to block α2 - and α2 adrenoceptor(α1/α2)was 60. these results indicate that 86040 is a potentant relatively selective α1 - adrenoceptor blocker.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第3期188-190,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助课题
关键词
四氢异喹啉
肾上腺素受体
tetrahydroisoquinoline 86040
adrenoceptor
vas deferens
anococcygeus muscle
